Antibiotic Year Application History

In 1877, Pasteur and Joubert first realized that microbial products might become therapeutic drugs. They published an experimental observation that ordinary microorganisms could inhibit the growth of anthrax in urine.

In 1928, Sir Fleming discovered penicillium, which can kill deadly bacteria. Penicillin cured syphilis and gonorrhea without any obvious side effects at that time.

In 1936, the clinical application of sulfanilamide initiated a new era of modern antimicrobial chemotherapy.

In 1944, the second antibiotic streptomycin was isolated from the University of New Jersey, which effectively cured another terrible infectious disease: tuberculosis.

In 1947, chloramphenicol appeared. It was mainly aimed at dysentery and anthrax, and was used to treat mild infections.

In 1948, tetracycline appeared, which was the earliest broad-spectrum antibiotic. At that time, it seemed that it could be used effectively without diagnosis. In modern society, tetracycline is basically only used for livestock breeding.

In 1956, Lilly Company invented vancomycin, which is called the last weapon of antibiotics. Because it has a triple bactericidal mechanism against the cell wall, cell membrane and RNA of G+bacteria, it is not easy to induce bacteria to become resistant to it.

In the 1980s, quinolones appeared. Unlike other antimicrobial agents, they destroy bacterial chromosomes and are not affected by gene exchange resistance.