Morphological changes of apoptosis

Morphological observation shows that the changes of apoptosis are multi-stage, and apoptosis often involves a single cell, even a small part of cells are asynchronous. First, the cell volume shrinks, the connection disappears, and the cell separates from the surrounding cells. Then, the density of the cytoplasm increases, the mitochondrial membrane potential disappears, and the permeability changes. Cytochrome C is released into the cytoplasm, the nucleoplasm is concentrated, the nucleolus of the nuclear membrane is broken, and DNA is degraded into about 180bp-200bp fragments; The cell membrane has vesicular formation, the phosphatidylserine inside the membrane is everted to the surface of the membrane, and the cell membrane structure is still intact. Finally, the remains of apoptotic cells can be divided and wrapped into several apoptotic bodies without content overflow, so it does not cause inflammation around. The apoptotic bodies can be quickly engulfed by the surrounding full-time or part-time phagocytes.