BAY2402234 CAS No.:2225819-06-5

BAY2402234 CAS No.:2225819-06-5

BAY2402234, also known as (4S,5R)-4-(4-(2-Chloro-4-(trifluoromethoxy)phenyl)piperazin-1-yl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one is a novel small molecule inhibitor that has been developed as a potent and selective inhibitor of a specific kinase. The compound has demonstrated promising results in pre-clinical studies for the treatment of several diseases, including cancer and inflammation.

Key Features of BAY2402234

1. Selectivity - It is a highly selective inhibitor of a specific kinase, and has minimal off-target effects.

2. Potency - It exhibits high potency in inhibiting the activity of its target kinase with an IC50 of < 0.100 nM.

3. Pharmacokinetics - It has demonstrated favorable pharmacokinetic properties, with good oral bioavailability in pre-clinical models.

4. Efficacy - It has shown significant efficacy in pre-clinical models of several diseases, such as cancer and inflammation.

5. Safety - It has demonstrated good safety profile in pre-clinical studies, with no significant toxicity or adverse effects observed.

Applications of BAY2402234

1. Cancer - The compound has shown significant anti-tumor activity in pre-clinical models of various cancers, such as breast, lung, prostate, and colon cancers. It inhibits the growth of cancer cells by blocking a specific kinase that is involved in cancer cell proliferation and survival.

2. Inflammation - The compound has also shown promising results in pre-clinical models of inflammation. It reduces the production of pro-inflammatory cytokines and chemokines by inhibiting the activity of a specific kinase that is involved in the inflammatory response.

3. Other Diseases - The compound has also been evaluated in pre-clinical models of other diseases, such as diabetes and Alzheimer's disease. It has shown potential therapeutic effects in these diseases by targeting specific kinases that are involved in the pathogenesis of these diseases.

Conclusion

BAY2402234 is a novel small molecule inhibitor that has demonstrated promising results in pre-clinical studies for the treatment of several diseases, including cancer and inflammation. The compound is highly selective, potent, and safe, with favorable pharmacokinetic properties. It has the potential to be developed into a valuable therapeutic agent for the treatment of various diseases. As a manufacturer, we are committed to providing high-quality products and services to our customers. We welcome inquiries and orders from merchants outside of China who are interested in our products. Please feel free to contact us to learn more about BAY2402234 and our other products.

Chemical Structure : BAY 2402234

CAS No.: 2225819-06-5

 

 

 

 

BAY 2402234 (Orludodstat, BAY2402234, BAY-2402234)

Catalog No.: URK-V692 Only Used For Lab.

BAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM (human full-length DHODH).

Biological Activity

Orludodstat (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM (human full-length DHODH).
BAY2402234 binds the ubiquinone binding site of DHODH between the N-terminal helices.
BAY2402234 causes dose-dependent upregulation of CD11b with EC50s of 3.16 nM in MOLM-13 cells and 0.96 nM in HEL cells, inhibits the proliferation of THP-1 cells with an IC50 of 2.6 nM, as well as nine other leukemia cell lines representing diverse AML subtypes (IC50=0.08-8.2 nM).
BAY 2402234 shows monotherapy efficacy and differentiation induction across multiple AML subtypes both in vitro and in vivo.

Physicochemical Properties

References

1. Christian S, et al. Leukemia. 2019 Apr 2. doi: 10.1038/s41375-019-0461-5.

URK-V692_COA

URK-V692_SDS

URK-V692_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

Why choose us?

• We understand the importance of getting it right the first time and always strive for perfection.
• Our intention is to assist clients understand their ambitions.
• Our commitment to quality ensures that our products will meet or exceed our customers' expectations.
• While meeting the needs of mass consumption, we further meet the requirements of diversified development trends.
• We strive to provide the best possible service to ensure our customers' satisfaction.
• Our high degree of automation and precise control ensure the quality of product production and quality.
• Our focus on customer satisfaction has earned us a loyal and satisfied customer base.
• The company has complete sets of advanced production lines and supporting facilities, scientific research equipment and testing instruments required for mass production of BAY2402234 CAS No.:2225819-06-5.
• We offer a range of services to help our customers meet their unique needs and requirements.
• We will adhere to the business philosophy of customer service and continuous improvement, and reward our customers with first-class products and services.

Hot Tags: bay2402234 cas no.:2225819-06-5, China bay2402234 cas no.:2225819-06-5, epigenetic library for epigenetic analysis of epigenetic reprogramming, agonists for inflammation research, nf b pathway lipidomics, agonists for targeted therapy, epigenetic library for epigenetic network, epigenetic library for epigenetic attenuation