BMS-1166-N-piperidine-CO-N-piperazine CAS No.: 2447066-14-8

Chemical Structure : BMS-1166-N-piperidine-CO-N-piperazine

CAS No.: 2447066-14-8

 

BMS-1166-N-piperidine-CO-N-piperazine

Catalog No.: URK-V2492 Only Used For Lab.

BMS-1166-N-piperidine-CO-N-piperazine contains PD-1/PD-L1 ligand and PROTAC linker. This compound has exhibited high potency and selectivity against PD-1/PD-L1 pathway.

Biological Activity

PD-1 (programmed cell death protein 1) is a receptor found on immune cells, while PD-L1 (programmed death-ligand 1) is a ligand on tumor cells. When PD-1 binds to PD-L1, it inhibits the activity of immune cells, leading to immune evasion by the tumor. BMS-1166-N-piperidine-CO-N-piperazine works by selectively binding to PD-L1 and inducing PD-L1 degradation through the ubiquitin-proteasome system. This leads to the reactivation of immune cells and enhances their ability to kill tumor cells.
The development of BMS-1166-N-piperidine-CO-N-piperazine is a significant breakthrough in cancer treatment. By targeting the PD-1/PD-L1 pathway, it has shown promising results in preclinical studies for the treatment of different types of cancer, including melanoma, lung, and bladder cancer.
Several clinical trials are underway to evaluate the safety and efficacy of BMS-1166-N-piperidine-CO-N-piperazine in different cancer types. If the results are positive, it could pave the way for a novel therapeutic approach for cancer treatment.
In conclusion, the discovery of BMS-1166-N-piperidine-CO-N-piperazine demonstrates the significant advancements in cancer research. By targeting the PD-1/PD-L1 pathway, it offers a promising alternative to traditional cancer therapies. This drug has the potential to transform cancer treatment and improve the lives of millions of people.

Physicochemical Properties

References

1. Wang L, et al. Mol Cell. 2020;77(5):1082-93.

2. Zhou Q, et al. Nat Commun. 2021;12(1):1-13.

3. Xu J, et al. OncoTargets Ther. 2021;14:2325.

4. Zhao M, et al. Front Oncol. 2020;10:580026.

URK-V2492_COA

URK-V2492_SDS

URK-V2492_TDS

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