Suzhou Ureiko Medical Chemistry Technology Co.,Ltd, affiliated to Ureiko Group Co., Limited, is the world's leading supplier of scientific research chemicals and bioactive compounds, is always focus on R&D of signal transduction inhibitors and pharmaceutical intermediates. The product range covers a variety of inhibitors, agonists, and compound libraries. We follow closely the industry trend, and the latest research achievements in life science area.
Why choose us?
Our product
The product range covers a variety of inhibitors, agonists, and compound libraries, more than 10,000 specific inhibitors, agonists, and Libraries of over 100 active compounds
Product application
Ureiko is committed to providing industrial of small pharmaceutical molecules, fine chemicals, agricultural organic fertilizer, new building materials, electronic products, sporting goods, home daily necessities and so on, and become a comprehensive group company.
Production equipment
LCMS, HPLC, PreHPLC, NMR etc.
Types of Metabolic Enzyme/Protease Library
Serine proteases
These enzymes utilize a serine residue within their active site to catalyze peptide bond cleavage. Serine proteases play critical roles in digestion, blood clotting, and immune responses.
Cysteine proteases
These proteases employ a cysteine residue for catalysis and are found in various cellular processes, including apoptosis and protein degradation.
Metalloproteases
Metalloproteases require metal ions, such as zinc, for their catalytic activity. They are involved in diverse physiological functions, including tissue remodeling, cell signaling, and wound healing.
Aspartyl proteases
Aspartyl proteases use aspartic acid residues within their active sites to facilitate peptide bond hydrolysis. Examples of aspartyl proteases include pepsin, which functions in the acidic environment of the stomach to initiate protein digestion, and the HIV protease, which plays a crucial role in the replication of the human immunodeficiency virus.
Applications of Enzyme Libraries
Drug discovery and development
Enzyme libraries are invaluable in the pharmaceutical industry for the synthesis of drug precursors and the development of diagnostic tools. For example, protease and glycosidase libraries are essential for antibody research and therapeutic enzyme development.
Diagnostics and bioanalysis
Diagnostic assays rely on enzymes to detect biomarkers, pathogens, or metabolites. Our enzyme libraries include key candidates for developing innovative assays such as enzyme-linked immunosorbent assays (ELISA) or glucose biosensors.
Industrial biocatalysis
Enzymes from our libraries drive efficiency in chemical synthesis, reducing energy consumption and environmental impact. Examples include lipases for biodiesel production and cellulases for bioethanol production.
Food and beverage processing
From improving the texture of bread to clarifying juices, enzyme libraries offer solutions to enhance food quality and processing efficiency. Libraries of amylases, proteases, and pectinases are particularly relevant in this area.
Environmental applications
Our enzyme libraries contribute to sustainability by supporting the degradation of pollutants, recycling plastics, or converting waste into valuable products. Libraries of laccases and PETase enzymes are particularly suited for environmental applications.
Synthetic biology and metabolic engineering
Enzyme libraries are foundational tools in synthetic biology, enabling the construction of tailored metabolic pathways for producing biofuels, specialty chemicals, and pharmaceuticals.
Substrate availability
The substrate is a kind of molecule that is attached to the enzyme with the characteristics of affinity and the kinetic parameter called the Km. If the accumulation of the substrate inside the cell is more than Km, then the enzyme site will have substrate saturation. In this case, the enzyme will be hyperactive.
Product inhibition
In a catalyzed reaction, the product of an enzyme is usually similar to the reactant that started the reaction. In this case, the product gets attachment with the activity site with lower levels of affinity. In conditions in which the product of the reaction is available in a higher concentration, it is important for the cell to not move towards more product synthesis. In this case, product inhibition can be closely seen. Likewise, it can be better for a cell if the end product at the entire pathway can be tied-up to the initial enzyme in the pathway.
Allosteric regulation
All pathways in a metabolic process are in connection with each other. Thus, molecules that tie-up at the site of the target enzyme can regulate the target enzymes at the other sites as well. In fact, these molecules may be structurally different from those that tie-up at the active site. They do this by conformational changes that may either activate or hinder the activity of the target enzyme.
PH and enzyme confirmation
Even a minute modification in the PH can lead to different metabolic processes like respiration to modify the conformation of the enzyme and the activity of the enzyme. Changes in the initial phase are covalent. This means that it can result in the alternation of a delicate balance of force that may affect the structure of the protein.
PH and the protonation stage
Modification in the PH levels can also impact the protonation phase of different amino-acid changes. But, it does not lead to global or local confirmation of any protein. If the mechanism of the catalysis leads to active site nucleophiles, it can change the catalysis process.
Covalent changes
Most proteins go through post-translational changes. These affect the activity of the enzyme in different locales as well as global shape modification. This can happen due to the promotion or due to inhibition of the binding interaction of substrates as well as the allosteric regulators. It can also happen due to the change in the location of the protein inside the cell.
Physicochemical Properties
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M.Wt |
381.35 |
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Formula |
C21H14F3N3O |
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CAS No. |
2446880-46-0 |
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Appearance |
Solid |
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Storage |
Solide Powder -20 °C 3years; 4°C 2years |
In Solvent -80°C 6 Months -20°C 1 Months |
Certificate
FAQ
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