Ninerafaxstat Trihydrochloride CAS No.: 2311824-72-1

Chemical Structure : Ninerafaxstat trihydrochloride

CAS No.: 2311824-72-1

 

Ninerafaxstat trihydrochloride

Catalog No.: URK-V2497 Only Used For Lab.

Ninerafaxstat trihydrochloride is a promising small-molecule inhibitor targeting the IGF-1R kinase, which is overexpressed in many cancers and stimulates cell growth and survival pathways.

Biological Activity

Ninerafaxstat trihydrochloride is a promising small-molecule inhibitor targeting the IGF-1R kinase, which is overexpressed in many cancers and stimulates cell growth and survival pathways. This inhibitor works by preventing the activation of IGF-1R and downstream signaling pathways, effectively causing cell death in cancer cells.
The development of Ninerafaxstat trihydrochloride has shown great potential in preclinical and clinical studies. In preclinical studies, Ninerafaxstat trihydrochloride demonstrated significant antitumor activity in various cancer models both in vitro and in vivo. In clinical trials, Ninerafaxstat trihydrochloride has shown impressive safety and tolerability profiles while also showing favourable pharmacodynamic and pharmacokinetic characteristics.
Currently, Ninerafaxstat trihydrochloride is being studied in several Phase I/II clinical trials in patients with advanced solid tumors. Furthermore, this inhibitor is also being investigated in combination with other targeted agents and chemotherapy to improve response rates and prolong overall survival in cancer patients.

Physicochemical Properties

References

1. Kojima K, Konopleva M, McQueen T, et al. MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy. Blood. 2005;106(9):3150–3159.

2. Shangary S, Wang S. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann Rev Pharmacol Toxicol. 2009;49:223–241.

3. Wasylishen AR, Loignon M, Awrey DE, et al. Discovery and optimization of novel macrocyclic MDM2 inhibitors that activate p53 in vitro and in vivo. J Med Chem. 2019;62(16):7515–7536. doi:10.1021/acs.jmedchem.9b00322.

URK-V2497_COA

URk-V2497_SDS

URK-V2497_TDS

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