GSK484 Hydrochloride CAS No.: 1652591-81-5

GSK484 Hydrochloride CAS No.: 1652591-81-5 Introduction

GSK484 Hydrochloride is a novel and potent inhibitor of the bacterial enzyme Mtb GlmU acetyltransferase, which has been implicated in the synthesis of peptidoglycan, an essential component of bacterial cell walls. As a result, GSK484 shows promising potential as a new therapeutic agent against tuberculosis, one of the world's leading infectious diseases and a major cause of morbidity and mortality worldwide.

Manufactured by our company in China, GSK484 Hydrochloride is a high-quality product that has been rigorously tested and validated for use in a range of research applications, including drug discovery, bacterial pathogenesis, and drug resistance studies. Our commitment to quality and reliability is reflected in our rigorous quality control procedures and our strict adherence to international standards and regulations.

GSK484 Hydrochloride is a promising new compound for the treatment of TB, as it offers a novel mechanism of action that targets the bacterial cell wall and has the potential to overcome drug resistance. Unlike other drugs that target the TB bacterium, such as isoniazid and rifampin, which act on enzymes involved in the synthesis of nucleic acids, GSK484 targets a different enzyme that is critical to the integrity of the bacterial cell wall.

The effectiveness of GSK484 has been demonstrated in a number of preclinical studies, which have shown that it can inhibit the growth of drug-resistant strains of Mtb and has a synergistic effect when used in combination with other anti-TB drugs. In addition, its unique mechanism of action means that it is less likely to be affected by resistance mechanisms that can arise with other drugs, making it a promising candidate for the treatment of multidrug-resistant TB.

In addition to its potential as a therapeutic agent, GSK484 also has important applications in the field of bacterial pathogenesis and drug resistance studies. The ability to selectively inhibit the activity of GlmU acetyltransferase provides a valuable tool for elucidating the role of this enzyme in bacterial cell wall synthesis and for identifying novel targets for drug development.

At our China-based manufacturing facility, we use state-of-the-art processes and equipment to produce GSK484 Hydrochloride to the highest standards of quality and purity. Our team of experienced scientists and technicians oversee every aspect of the production process, from raw materials sourcing to final product testing, to ensure that our customers receive a reliable and consistent product that meets their needs.

We are committed to providing our customers with the highest level of service and support, and are always available to answer any questions you may have about our products, our manufacturing processes, or our quality control procedures. Whether you are a researcher looking for a reliable source of GSK484 Hydrochloride for your studies, or a pharmaceutical manufacturer looking for a new therapeutic agent for TB, we are here to help.

In conclusion, GSK484 Hydrochloride is a high-quality product that offers a promising new therapeutic approach for the treatment of TB, as well as important applications in the fields of bacterial pathogenesis and drug resistance studies. Produced to the highest standards of quality and purity by our experienced team of scientists and technicians in China, it is a reliable and consistent source of this important compound. We welcome the opportunity to work with you and to help you achieve your research or commercial goals with the use of our product.

Chemical Structure : GSK-484 hydrochloride

CAS No.: 1652591-81-5

 

GSK-484 hydrochloride(GSK484)

Catalog No.: URK-V2361 Only Used For Lab.

GSK-484 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), 50 nM in PAD4 NH3 release inhibition assay.

Biological Activity

GSK-484 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), 50 nM in PAD4 NH3 release inhibition assay.
GSK-484 shows high specificity for PAD4 over PAD1/2/3/6.
GSK-484 causes a clear, statistically-significant reduction in diffused NETs.

Physicochemical Properties

References

1. Lewis HD, et al. Nat Chem Biol. 2015 Mar;11(3):189-91.

2. Cedervall J, et al. Oncoimmunology. 2017 Apr 20;6(8):e1320009

URK-V2361_COA

URK-V2361_SDS

URK-V2361_TDS

 

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