Home - Products - ADCs And PROTACs - PROTAC - Details

MRT-2359 (MRT2359,MRT 2359) CAS No.: 2803881-11-8

Chemical Structure : MRT-2359
CAS No.: 2803881-11-8

Send Inquiry

Description

Chemical Structure : MRT-2359

CAS No.: 2803881-11-8

MRT-2359 (MRT2359,MRT 2359)

Catalog No.: URK-V2453 Only Used For Lab.

MRT-2359 (MRT2359) is a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader with DC50 of 5 nM in CAL51 cell line (Dmax=100%).

Biological Activity

MRT-2359 (MRT2359) is a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader with DC50 of 5 nM in CAL51 cell line (Dmax=100%).
The target of MRT-2359 is a protein family called Cyclin-dependent kinases (CDKs). These enzymes are essential for cell division, and mutations in CDKs have been linked to various types of cancer. MRT-2359 is designed to inhibit the activity of specific CDKs, thereby halting the growth of cancer cells and preventing the formation of new tumors.
Several preclinical studies have demonstrated the efficacy of MRT-2359 against various types of cancer, including breast, lung, and colorectal cancers. In these studies, MRT-2359 has been shown to slow down tumor growth, reduce the number of cancer stem cells, and improve the survival rates of treated animals.

Physicochemical Properties

M.Wt	495.39
Formula	C22H17F4N3O6
CAS No.	2803881-11-8
Appearance	Solid
Storage	Solide Powder -20 °C 3years; 4°C 2years	In Solvent -80°C 6 Months -20°C 1 Months
Solubility
Chemical Name	O=C(NC1=CC(OC(F)(F)F)=CC=C1F)OCC2=CC=C3C(C(N(C4C(NC(CC4)=O)=O)C3)=O)=C2