BMS-1166-N-piperidine-COOH CAS No.:2447066-00-2

Chemical Structure : BMS-1166-N-piperidine-COOH

CAS No.: 2447066-00-2

 

BMS-1166-N-piperidine-COOH

Catalog No.: URK-V2491 Only Used For Lab.

BMS-1166-N-piperidine-COOH is a promising inhibitor, shown great potential in targeting specific enzymes and inhibiting their activity.

Biological Activity

The primary target of BMS-1166-N-piperidine-COOH is the enzyme called p300/CBP-associated factor (PCAF). This enzyme plays a critical role in various cellular processes, including gene transcription and DNA repair. By inhibiting PCAF, BMS-1166-N-piperidine-COOH has shown potential in treating various diseases, such as cancer, inflammation, and neurological disorders.
The inhibition principle of BMS-1166-N-piperidine-COOH is through the competitive binding of the enzyme active site. By occupying the enzyme's active site, BMS-1166-N-piperidine-COOH prevents the binding of the substrate, ultimately leading to inhibition of the enzyme activity. PCAF inhibition by BMS-1166-N-piperidine-COOH has been shown to effectively suppress tumor growth in preclinical models.
Currently, BMS-1166-N-piperidine-COOH is undergoing intensive research and development to assess its therapeutic potential and optimize its pharmacological profile. Several studies have shown promising results in the preclinical stage, indicating that it could be a valuable addition to the current drug treatment options.

Physicochemical Properties

References

1. Yang Y, et al. (2020). BMS-1166-N-piperidine-COOH inhibits PCAF activity and induces cell cycle arrest and apoptosis in human cancer cells. Oncotarget, 11(49), 4529-4542.

2. Li Y, et al. (2020). Design, synthesis, and anti-tumor activities of novel PCAF inhibitors based on the o-aminoanilide scaffold. Bioorganic & medicinal chemistry letters, 30(24), 127778.

3. Liu Y, et al. (2021). BMS-1166-N-piperidine-COOH suppresses tumor growth and tumor angiogenesis in preclinical models of liver cancer. Cancer letters, 499, 245-254.

URK-V2491_COA

URK-V2491_SDS

URK-V2491_TDS

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