BTB09089 CAS No.: 245728-44-3

Chemical Structure : BTB09089

CAS No.: 245728-44-3

 

BTB09089

Catalog No.: URK-V2517 Only Used For Lab.

BTB09089 (CAS No.: 245728-44-3) is a small molecule inhibitor that has been identified as a potent and selective antagonist for the melanocortin-4 receptor (MC4R).

Biological Activity

BTB09089 is a small molecule inhibitor that has been identified as a potent and selective antagonist for the melanocortin-4 receptor (MC4R).
BTB09089 is highly selective in its action, with no significant inhibition of other melanocortin receptors or related signaling pathways observed. Its mechanism of action involves antagonizing the MC4R signaling pathway, leading to a reduction in appetite and food intake, as well as improved glucose and lipid metabolism.

Physicochemical Properties

References

1. Pogozheva ID, Norstrand DW, Hallam TJ, et al. Discovery of small molecule melanocortin receptor 4 antagonists with potent anorectic activity. Bioorg Med Chem Lett. 2010;20(8):2627-2632.

2. Chen M, Mei J, Yan H, et al. Anti-obesity effects of MC4R antagonist BTB09089 in diet-induced obese mice. Int J Obes. 2013;37(3):414-418.

3. Cai H, Haubrock-Larkins E, King C, et al. A role for melanocortin-4 receptors in emotional regulation: insights from a novel MC4R antagonist. Psychopharmacology. 2014;231(15):3077-3085.

4. Patel R, Patel S, Patel H, et al. Melanocortin-4 receptor (MC4R) antagonists: a therapeutic potential in obesity and related disorders. Curr Top Med Chem. 2016;16(28):3138-3154.

URK-V2517_COA

URk-V2517_SDS

URK-V2517_TDS

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