RV521 CAS No.: 1903763-82-5

Introduction

RV521 CAS No.: 1903763-82-5 is a highly effective inhibitor of bromodomain-containing protein 4 (BRD4), which plays a vital role in regulating gene expression. It has been extensively tested in different cellular and animal models, demonstrating potent anti-cancer and anti-inflammatory activities. As a leading manufacturer of high-quality pharmaceutical products in China, we are committed to providing merchants from all around the world with premium quality products at competitive prices.

Product Description

RV521 is a small molecule with a molecular weight of 438.5 g/mol, which belongs to the class of thienotriazolodiazepine derivatives. The chemical structure of RV521 is shown in Figure 1.

Figure 1: Chemical structure of RV521

RV521 inhibits the activity of BRD4, which is a member of the bromodomain and extra-terminal domain (BET) protein family, involved in the epigenetic regulation of gene expression. BRD4 binds to acetylated lysines on histones, promoting the recruitment of transcriptional coactivators and RNA polymerase II, enabling transcriptional elongation. Aberrant activation of BRD4 has been implicated in several types of cancer, including leukemia, lymphoma, and solid tumors.

RV521 acts as a selective antagonist of BRD4, inhibiting its binding to acetylated histones, disrupting its interaction with transcriptional coactivators, and consequently, blocking the transcriptional elongation of oncogenic genes. It has been shown to induce cell cycle arrest, apoptosis, and senescence in cancer cells, resulting in the suppression of tumor growth in various animal models.

RV521 also exhibits potent anti-inflammatory properties by inhibiting the production of cytokines and chemokines, such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ), which play a critical role in the pathogenesis of autoimmune and inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. RV521 has the potential to become a new-generation therapy for cancer and inflammatory diseases, with a favorable safety profile and pharmacokinetics.

Product Features

• High Purity: RV521 is synthesized using state-of-the-art technology and undergoes rigorous quality control measures to ensure its purity level exceeds 98%.

• Potent Inhibitory Activity: RV521 exhibits potent and selective inhibition of BRD4, with an IC50 value in the nanomolar range.

• Broad Spectrum Activity: RV521 displays anti-cancer and anti-inflammatory activities, targeting multiple oncogenic and inflammatory pathways.

• Good Safety Profile: RV521 has been extensively evaluated in preclinical studies, showing low toxicity, and good pharmacokinetics.

• Versatile Applications: RV521 can be used in various assays, including cellular, biochemical, and animal models, making it a useful tool for research and drug discovery.

Product Applications

• Cancer Research: RV521 can be used to elucidate the role of BRD4 in cancer biology and to identify novel therapeutic targets.

• Drug Discovery: RV521 can be used to screen for new drugs targeting BRD4 and to evaluate their efficacy and safety in animal models.

• Inflammation Research: RV521 can be used to investigate the role of BRD4 in immune regulation and to identify new targets for immunomodulatory therapies.

Merits of Our Products

• Competitive Price: We offer our products at highly competitive prices, ensuring merchants from all around the world can access premium quality products at an affordable cost.

• Superior Quality: We prioritize quality control measures to ensure our products meet or exceed industry standards, giving merchants peace of mind that they are receiving a high-quality product.

• Fast Delivery: We strive to deliver our products as quickly and efficiently as possible, minimizing delays and ensuring merchants can receive their products in a timely manner.

Conclusion

RV521 CAS No.: 1903763-82-5 is a highly effective inhibitor of BRD4, demonstrating potent anti-cancer and anti-inflammatory activities. This product has high purity, a broad spectrum of activity, a good safety profile, and versatile applications. As a leading manufacturer of high-quality pharmaceutical products in China, we are committed to providing merchants from all around the world with premium quality products at competitive prices. We prioritize quality control measures, fast delivery, and excellent customer service, ensuring that merchants can receive our products with confidence, and use them to advance their research and drug discovery efforts.

Chemical Structure : Sisunatovir

CAS No.: 1903763-82-5

 

RV521(Sisunatovir)

Catalog No.: URK-V607  Only Used For Lab.

RV521 (Sisunatovir) is a potent, orally active, small-molecule inhibitor of RSV fusion, demonstrates potent antiviral activity across multiple strains of RSV in vitro..

Biological Activity

RV521 (Sisunatovir) is a potent, orally active, small-molecule inhibitor of RSV fusion, demonstrates potent antiviral activity across multiple strains of RSV in vitro.

Physicochemical Properties

References

1. Yu-Ki Tahara, et al. J Am Chem Soc. 2018 Feb 14;140(6):2105-2114.

2. Qin S, et al. J Immunol. 2020 Oct 15;205(8):2231-2242.

3. Zhang L, et al. Redox Biol. 2021 Apr;40:101848.

URK-V607_COA

URK-V607_SDS

URK-V607_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

Why choose us?

• Our products are safe and reliable for use in a wide range of applications.
• 'Based on domestic market and expand overseas business' is our progress strategy for RV521 CAS No.: 1903763-82-5.
• We are a Chinese factory specialized in providing high-quality Antibiotics & Antivirals Library products and professional services.
• We have more than 15 years of industry experience, rich experience in marketing planning and practical operation, and strong execution
• Our products have been tested and verified by independent third-party agencies.
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• We provide customized solutions to meet the needs of our clients.
• Our company emphasizes that quality, safety and fast service are the core, and constantly meeting the needs of customers is the source of our company's efforts.
• We pride ourselves on our attention to detail and commitment to quality.
• The company always insists on "advanced concept, advanced management, advanced equipment and advanced technology" as the business purpose.

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