TP0586532 CAS No.: 2427584-96-9

TP0586532 CAS No.: 2427584-96-9 Product Introduction

TP0586532 refers to a chemical compound that is also known by its CAS number 2427584-96-9. It is a highly effective, selective and potent antagonist for a certain type of receptor. In recent years, TP0586532 has gained increasing popularity due to its widespread use in the industrial and academic sectors for research and development purposes.

TP0586532 compound belongs to the class of Pyrazoles, and it has a molecular weight of 433.91 g/mol. The compound is highly soluble in solvents like DMSO (Dimethyl Sulfoxide) and DMF (Dimethylformamide) while being relatively insoluble in water. TP0586532 is a highly selective and potent antagonist of a specific class of receptors that have been extensively researched.

The growing use of TP0586532 as a highly effective research reagent can be attributed to its ability to selectively block the activity of specific receptors in the central nervous system (CNS) responsible for transmission of information between nerve cells. This makes it an ideal molecule for targeted research into physiological and pathological states, drug discovery, and potential pharmacological intervention.

One of the most significant benefits of TP0586532 is that it has lower toxicity compared to other compounds with similar research applications. This makes it safer to use in research studies and can even contribute to the development of new pharmacological drugs that can be approved for medical use.

TP0586532 has found applications across numerous fields, including neuroscience, psychology, clinical pharmacology, and pharmacodynamics. In these fields, TP0586532 has been used to:

- Map the structural and functional connectivity of the CNS

- Develop a better understanding of the mechanism behind specific neurological disorders

- Identify novel drug targets for CNS diseases

- Examine the effects of potential novel drug therapies

TP0586532 is a versatile and essential research reagent for academia and industry. Researchers can utilize its activity on CNS-receptors to study neural processes and come up with novel drug therapies. The high specificity and relatively low toxicity of the compound make it a useful research tool that could lead to significant developments in the medical field.

TP0586532 is available from our manufacturing company, and we offer it in bulk, making it accessible to a broad range of researchers. Our company ensures that each batch of TP0586532 compound meets the highest quality standards, and we conduct rigorous testing to ensure its purity and effectiveness.

In conclusion, TP0586532 is a highly potent, selective, and effective antagonist of CNS receptors that has found widespread use in research for both industrial and academic sectors. Its diverse range of applications across numerous fields is a testament to its importance in furthering the understanding of the human nervous system and could lead to the development of new and exciting drug therapies.

Chemical Structure : TP0586532

CAS No.: 2427584-96-9

 

TP0586532 (TP 0586532)

Catalog No.: URK-V603  Only Used For Lab.

TP0586532 (TP 0586532) is a novel non-hydroxamate inhibitor of UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) with IC50 of 0.101 uM, shows MIC values 2 mg/mL and 4 mg/mL for E. coli ATCC 25922 and K. pneumoniae ATCC 13883.

Biological Activity

TP0586532 (TP 0586532) is a novel non-hydroxamate inhibitor of UDP-3-O-acyl-N--acetylglucosamine deacetylase (LpxC) with IC50 of 0.101 uM, shows MIC values 2 mg/mL and 4 mg/mL for E. coli ATCC 25922 and K. pneumoniae ATCC 13883; TP0586532 is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk. The MIC90 of TP0586532 against clinical isolates of carbapenem-resistant Klebsiella pneumoniae was 4 ug/mL. TP0586532 also showed an in vivo efficacy against murine systemic, urinary tract and lung infection models caused by meropenem- or ciprofloxacin-resistant strains. TP0586532 also reduces LPS release and IL-6 production both in vitro and in vivo.

Physicochemical Properties

References

1. Ushiyama F, et al. Bioorg Med Chem. 2021 Jan 15;30:115964.

2. Fujita K, et al. J Antibiot (Tokyo). 2022 Feb;75(2):98-107.

3. Fujita K, et al. J Antibiot (Tokyo). 2022 Mar;75(3):136-145.

URK-V603_COA

URK-V603_SDS

URK-V603_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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