PF06291874 CAS No.:1393124-08-7

Product Introduction:

PF06291874 CAS No.: 1393124-08-7 is a new and innovative product that has been designed to meet the needs of the market. As a manufacturer in China, we are committed to producing high-quality products that meet the demand of customers across the globe. With this in mind, we have created PF06291874, an industry-leading product that is designed to offer superior performance and value to merchants worldwide.

The product is a chemical compound with a molecular weight of 371.4 g/mol that is primarily used in the research and development of pharmaceuticals. The product is a yellow to orange crystalline powder that is soluble in organic solvents and has a melting point of 178-180°C. It is a high-purity material that meets the quality standards of our industry, and has been certified by international regulatory bodies.

PF06291874 CAS No.:1393124-08-7 is a well-regarded product in the chemical industry due to its outstanding properties. It is a potent inhibitor of pan-Raf, and is relatively selective for B-Raf V600E over wild-type B-Raf in cell-free assays. The product also inhibits mutant BRAF, CRAF, and cKIT, while demonstrating weak activity against FGFR1 and PDGFRα. These properties make it ideal for use in research and development of oncology drugs.

The high purity and quality of PF06291874 CAS No.:1393124-08-7 make it a versatile product that can be used in a wide variety of applications. In particular, it is ideal for use in oncology research and drug development. The product is also well-suited for use in biological assays such as biochemical and cell-based assays. It is an excellent option for customers looking for a high-quality compound to facilitate their research and development efforts.

One of our primary goals as a manufacturer is to provide our customers with the highest quality and most cost-effective products possible. PF06291874 CAS No.:1393124-08-7 is no exception - it offers exceptional value and performance in a competitive market. With our decades of experience and expertise in the chemical industry, we have been able to produce a product that is sure to meet and exceed the expectations of our customers.

In conclusion, PF06291874 CAS No.:1393124-08-7 is a top-of-the-line product that has been designed to meet the ever-increasing demands of the chemical industry. As a manufacturer, we are committed to providing customers with the highest quality products possible, and PF06291874 is no exception. With its outstanding properties and superior quality, it is an excellent choice for merchants worldwide looking for a dependable and cost-effective option in this ever-changing industry.

Chemical Structure : GCGR-IN-17

CAS No.: 1393124-08-7

 

GCGR-IN-17(PF-06291874;PF06291874;PF-6291874)

Catalog No.: URK-V735 Only Used For Lab.

PF06291874 (GCGR-IN-17) is a highly potent glucagon receptor antagonist with Ki of 14 nM for hGCGR.

Biological Activity

PF06291874 (GCGR-IN-17) is a highly potent glucagon receptor antagonist with Ki of 14 nM for hGCGR.
PF06291874 shows excellent selectivity against a panel of 69 receptors, ion channels, uptake sites and enzymes.
PF06291874 reduces the glucagon-elicited glucose excursion in a dose-dep endent manner in rats.
PF06291874 displays low in vivo clearance and excellent oral bioavailability in both rats and dogs.

Physicochemical Properties

References

1. Guzman-Perez A, et la. Bioorg Med Chem Lett. 2013 May 15;23(10):3051-8.

URK-V735_COA

URK-V735_SDS

URK-V735_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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