STM2457 CAS No.:2499663-01-1

Introduction:

Are you looking for a high-quality product at an affordable price? If so, let us introduce you to our newest offering: STM2457. This product is a versatile, multi-purpose chemical that can be used in a variety of industries, including pharmaceuticals and agriculture. It has a unique chemical structure and special properties that make it highly desirable for merchants looking for dependable and efficient products for their needs. Our company is proud to manufacture and distribute this product worldwide.

Product Description:

STM2457 is a highly pure, crystalline solid with a molecular formula of C23H24ClN7O3. It has a molecular weight of 485.9 and a melting point of 215-217°C. The chemical structure of STM2457 is complex, featuring a pyrimidine core attached to a pyridine with a phenyl ring, an alkoxy group, and a highly reactive amino group. Its unique structure makes it highly selective and suitable for a wide range of applications.

Applications:

STM2457 is primarily used as a chemical intermediate for the synthesis of other compounds. It can be used to produce a broad range of pharmaceuticals, including anti-cancer agents, anti-viral medications, and antibiotics. Additionally, it has applications in agriculture, where it is used as a pesticide and herbicide. It provides exceptional weed control and can effectively suppress many broadleaf and grassy weeds. It has excellent efficacy against difficult-to-control weeds such as ryegrass, foxtail, and black nightshade.

STM2457 is also suitable for use in the production of organic light-emitting diodes (OLEDs) and other advanced materials. Its unique chemical properties make it a valuable component in OLEDs, as it helps increase efficiency and brightness while lowering power consumption. It can also be used as a sensitizer for photodynamic therapy, helping to target and destroy cancer cells.

Advantages:

STM2457 has many advantages, making it a highly desirable product for merchants. Firstly, it is easy to handle and store, with long shelf life and stability under normal conditions. Secondly, it is highly pure and can be easily synthesized in large quantities, ensuring consistent quality and availability of supply. The product also has a broad spectrum of activity and can be used in a diverse range of fields, making it highly versatile and cost-effective. Finally, STM2457 is eco-friendly and has a low toxicity profile, making it safe for humans and the environment.

Conclusion:

STM2457 is a valuable product that has many excellent qualities and applications. With its unique chemical structure and properties, it is highly desirable for merchants in a variety of industries. Our company is proud to offer this product to our customers worldwide, and we are confident that you will be impressed with its quality, efficacy, and cost-effectiveness. Contact us today to learn more about how STM2457 can benefit your business.

Chemical Structure : STM2457

CAS No.: 2499663-01-1

 

STM2457(STM-2457)

Catalog No.: URK-V965 Only Used For Lab.

STM2457 (STM-2457) is a highly potent, selective first-in-class catalytic inhibitor of METTL3 with IC50 of 16.9 nM, binds to the METTL3-METTL14 with Kd of 1.4 nM.

Biological Activity

STM2457 (STM-2457) is a highly potent, selective first-in-class catalytic inhibitor of METTL3 with IC50 of 16.9 nM, binds to the METTL3-METTL14 with Kd of 1.4 nM; Treatment of STM2457 leads to reduced AML growth and an increase in differentiation and apoptosis. STM2457 reduces m6A levels on known leukaemogenic mRNAs and decreasse in their expression consistent with a translational defect. STM2457 impaired engraftment and prolonged survival in various mouse models of AML, specifically targeting key stem cell subpopulations of AML.

Physicochemical Properties

References

1. Yankova E, et al. Nature. 2021 May;593(7860):597-601.

2. Xu QC, et al. Oncogene. 2022 Jan 29. doi: 10.1038/s41388-022-02185-1.

URK-V965_COA

URK-V965_SDS

URK-V965_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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