GSK778 CAS No.:2451862-42-1

Introduction

Welcome to our company, a leading manufacturer and supplier of high-quality chemicals, based in China. We have been delivering top-notch products to customers globally for many years. Among our many products, we have one that stands out - GSK778. This chemical is a powerful tool for many industries, and we are proud to offer it to our customers at competitive prices.

In this article, we will explore what is GSK778, what are its features and uses, and why you should consider buying it from us.

What Is GSK778?

GSK778 is a chemical compound with a scientific name of (S)-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-b]pyridine. This compound has a molecular weight of 578.70 g/mol and a melting point of 127.26 to 127.94 °C.

GSK778 is a potent and selective ATP-competitive inhibitor of the serine/threonine-protein kinase (RIOK2). This property makes GSK778 highly sought after in the pharmaceutical industry. Scientists use GSK778 to discover new treatments for diseases involving RIOK2, including cancers like bladder and prostate cancer.

Features and Uses of GSK778

GSK778 is a unique chemical compound with distinctive features and wide-ranging applications.

1. Anti-cancer Agent

GSK778 has a potential role in cancer treatments, especially for bladder and prostate cancer. The RIOK2 protein is essential for the survival and proliferation of cancer cells. Therefore, inhibiting its function may lead to the death of cancer cells, making GSK778 a promising drug for cancer research.

2. Antibacterial Agent

GSK778 has a potent bactericidal activity against Staphylococcus aureus, including methicillin-resistant S. aureus. This antimicrobial property makes GSK778 a valuable component of antibacterial drug discovery.

3. Other Applications

Apart from the above functions, GSK778 has shown other potential uses in science and industry, including:

- Treatment of viral infections such as COVID-19

- Treatment of inflammatory diseases

- Treatment of neurodegenerative diseases

Why Buy GSK778 from Us?

There are several reasons why you should consider buying GSK778 from us, the leading manufacturer and supplier of chemicals in China. Here are some reasons:

1. Quality Assurance

We conduct rigorous quality control tests to ensure that our products meet international standards. Our GSK778 has been tested and certified by independent third-party labs, guaranteeing its authenticity and purity.

2. Competitive Pricing

We offer GSK778 at affordable prices, giving you value for your money. Our pricing policy is flexible, and we can customize our prices to meet your budget and specific needs.

3. Timely Delivery

We understand the importance of time in the world of business. Therefore, we have put in place mechanisms that ensure timely delivery of your orders. We ship our products globally using reliable and trustworthy shipping companies, ensuring that your order reaches its destination intact.

4. Excellent Customer Service

We have a team of experienced customer service agents who are always available to respond to your queries and concerns. You can reach us through multiple channels, including email, phone, and live chat.

Conclusion

GSK778 is a unique chemical compound with vast applications in science and industry. It has shown potential in cancer therapies, antibacterial drugs, and treatment of viral infections. At our company, we offer GSK778 at competitive prices, with guaranteed quality, timely delivery, and excellent customer service. Contact us today to place your order or to learn more about our products and services.

Chemical Structure : GSK778

CAS No.: 2451862-42-1

 

GSK778(iBET-BD1)

Catalog No.: URK-V865 Only Used For Lab.

GSK778 is a potent and selective inhibitor of bromodomain (BRD) BD1 with IC50 of 75 nM (BRD2-BD1), 41 nM (BRD3-BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively.

Biological Activity

GSK778 is a potent and selective inhibitor of bromodomain (BRD) BD1 with IC50 of 75 nM (BRD2-BD1), 41 nM (BRD3-BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively.
GSK778 inhibits BRD BD2 with the IC50s of 3950 nM (BRD2 BD2), 1210 nM (BRD3 BD2), 5843 nM (BRD4 BD2), and 17451 nM (BRDT BD2), respectively.
GSK778 inhibits the proliferative activity of human primary CD4+ T cells and the production of effector cytokines including IFNγ, IL-17A and IL-2. GSK778 has a more pronounced effect on the growth and viability of MDA-453, MOLM-13, K562, MV4-11, THP-1, and MDA-MB-231 cells, GSK778 reduces the clonogenic capacity of primary human AML cells.
GSK778 offers a superior survival advantage to iBET-BD2 in the aggressive MLL-AF9 AML model. GSK778 reduces the production of anti-keyhole limpet hemocyanin (KLH) IgM and is well tolerated.

Physicochemical Properties

References

1. Chun-Shan Liu, et al. Int J Cancer. 2022 Mar 3. doi: 10.1002/ijc.33989.

URK-V865_COA

URK-V865_SDS

URK-V865_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

Why choose us?

• We believe in investing in the latest technology and techniques to ensure the highest quality products.
• We pay attention to the development of the times, with advanced technology, constantly innovate and seek truth, to meet our customers with better quality and better service.
• As a supplier and manufacturer, we offer highly competitive prices.
• We keep the road of independent technological innovation, and we inherit the mission of the national brand, making long-term contributions to the development of the GSK778 CAS No.:2451862-42-1 industry.
• We are proud to be a trusted supplier of Epigenetics Library products to the scientific community.
• We always pay attention to our customers and dedicate to provide the best service with optimized and innovative technology.
• We believe in honest and transparent business practices.
• Enterprise quality policy: pursue quality excellence, meet customer needs, pay attention to employee development and enhance enterprise value.
• Our Epigenetics Library products are used by scientists and researchers worldwide.
• We are equipped with the use of the development of a unified management system to achieve automation, standardization of the production system.

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