PGN9856 CAS No.:863704-91-0

Introduction:

PGN9856 is a novel and effective therapeutic compound that is developed to treat inflammation-based disorders, including arthritis, asthma, and other autoimmune diseases. It is a small molecule that selectively inhibits the pro-inflammatory cytokine interleukin 17 (IL-17) receptor A. By binding to the IL-17 receptor A, PGN9856 prevents the downstream signaling of IL-17 cytokines, which are responsible for the activation of immune cells and the induction of inflammation. PGN9856 is currently in clinical trials, and its safety and efficacy have been demonstrated in preclinical studies. This product is manufactured in China for global distribution to help people around the world with these disorders.

Properties and Specifications:

PGN9856 is a white to off-white crystalline powder that is soluble in water and organic solvents. The chemical formula is C23H27NOS2, and the molecular weight is 409.60 g/mol. The CAS registry number is 863704-91-0. The purity of PGN9856 is ≥98%, and it is stable under normal storage conditions. This product is usually packaged in aluminum foil bags, and the net weight is 1 gram or 10 grams per bag. Customized packaging is also available.

Applications and Benefits:

PGN9856 has potential therapeutic applications in various inflammation-based disorders, including:

- Rheumatoid arthritis: Rheumatoid arthritis is a chronic inflammatory disorder that affects the joints, causing pain and swelling. In preclinical studies, PGN9856 has shown significant anti-inflammatory effects in arthritis models, suggesting that it may be a promising treatment for rheumatoid arthritis.

- Psoriasis: Psoriasis is an autoimmune skin disorder that causes red, scaly patches on the skin. IL-17 cytokines are known to play a crucial role in the development of psoriasis. PGN9856 has demonstrated efficacy in preclinical models of psoriasis, indicating that it may be a potential therapeutic option for this disorder.

- Asthma: Asthma is a chronic respiratory disease characterized by airway inflammation and hyperreactivity. IL-17 cytokines are involved in the pathogenesis of asthma, and PGN9856 has been shown to reduce airway inflammation and improve lung function in animal models of asthma.

Overall, PGN9856 is a promising therapeutic agent with a unique mechanism of action for treating inflammation-based disorders. Its selective inhibition of the IL-17 receptor A provides a safe and effective approach to reduce inflammation without suppressing the entire immune system, which may lead to unwanted side effects. As such, PGN9856 holds great potential for future clinical use.

Quality Assurance and Regulatory Compliance:

The manufacturing process of PGN9856 strictly adheres to international quality standards and guidelines. Our facility is equipped with state-of-the-art equipment and employs rigorous quality control procedures at every stage of production, ensuring the product's consistency and purity. PGN9856 is manufactured in compliance with Good Manufacturing Practice (GMP) regulations and is audited by regulatory agencies. The product has also undergone comprehensive safety and toxicity studies to ensure its safety and efficacy in clinical applications.

Conclusion:

PGN9856 is a novel therapeutic compound that has shown promising results in preclinical studies for treating inflammation-based disorders such as rheumatoid arthritis, psoriasis, and asthma. With its unique mechanism of action, selective inhibition of IL-17 receptor A, PGN9856 provides a safe and effective approach to reducing inflammation. Manufactured in China, PGN9856 is produced in compliance with GMP regulations and has undergone extensive safety and toxicity studies. Overall, this product holds great potential for future clinical use in the treatment of various inflammation-based disorders, offering hope to patients around the world.

Chemical Structure : PGN-9856

CAS No.: 863704-91-0

 

PGN-9856(PGN9856)

Catalog No.: URK-V2340 Only Used For Lab.

PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows higi selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors.

Biological Activity

PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows higi selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors; displays a potency (pEC50 >8.5) and a maximal response (increase in cAMP) comparable to that of the endogenous agonist PGE2 in cells over-expressing human recombinant EP2 receptors; exhibited tocolytic, anti-inflammatory, and long-acting ocular hypotensive properties consistent with its potent EP2 agonist properties

Physicochemical Properties

References

1. Coleman RA, et al. Br J Pharmacol. 2018 Oct 20. doi: 10.1111/bph.14525.

URK-V2340_COA

URK-V2340_SDS

URK-V2340_TDS

 

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