INCB057643 CAS No.: 1820889-23-3

INCB057643 CAS No.: 1820889-23-3 is a potent and selective inhibitor of BRD9, a bromodomain-containing protein that has been implicated in various diseases, including cancer, inflammation, and neurological disorders. As a manufacturer based in China, we are proud to offer this high-quality product to merchants worldwide.

The mechanism of action for INCB057643 is based on its ability to bind specifically to the bromodomain of BRD9, inhibiting its interaction with chromatin and preventing the recruitment of transcriptional coactivators that are necessary for the transcription of target genes. This leads to the downregulation of specific oncogenes and pathways that are involved in the proliferation and survival of cancer cells, as well as the modulation of inflammatory and immune responses.

One of the key advantages of INCB057643 is its selectivity and potency. It has been shown to have minimal off-target effects on other bromodomain-containing proteins, reducing the risk of unwanted side effects in patients. It also exhibits a high degree of potency, with IC50 values in the low nanomolar range, making it effective at relatively low concentrations.

Another important feature of INCB057643 is its potential for use in combination with other therapies. It has been shown to enhance the efficacy of standard of care treatments for multiple myeloma and acute myeloid leukemia, suggesting that it could be used as part of a combination therapy approach to improve patient outcomes.

In terms of application, INCB057643 is primarily intended for use in the pharmaceutical industry, where it has the potential to be developed into novel therapeutics for a range of diseases. It could also be used in academic and industrial research settings to better understand the role of BRD9 in disease pathology, and to screen for potential new drugs or drug targets.

As a manufacturer, we are committed to ensuring the highest quality of our products. INCB057643 is manufactured under strict quality control standards in our state-of-the-art facilities, and is tested extensively to ensure its potency, purity, and stability. We also offer competitive pricing and flexible ordering options to make it accessible to a wide range of merchants and researchers.

In summary, INCB057643 CAS No.: 1820889-23-3 is a highly potent and selective inhibitor of BRD9, with potential application in the treatment of various diseases, as well as for research purposes. Its selectivity, potency, and potential for combination therapy make it an attractive option for pharmaceutical companies and researchers alike. As a manufacturer based in China, we are proud to offer this high-quality product to merchants around the world.

Structure: INCB 057643

CAS No.: 1820889-23-3

Purity: >98%(HPLC)

 

INCB 057643(INCB057643, INCB-057643)

Catalog No.: URK-V594  Only Used For Lab.

INCB 057643 is a novel selective, potent orally bioavailable BET inhibitor.

Biological Activity

INCB 057643 is a novel selective, potent orally bioavailable BET inhibitor, bind to the motifs that recognize the acetylated lysines in the BRD region of the BET protein, thus preventing the interaction of the BET protein with the histone acetylated lysines.
Solid Tumors
Phase 2 Clinical

Physicochemical Properties

References

1. Wilson AJ, et al. Gynecol Oncol. 2018 Mar 20. pii: S0090-8258(18)30229-4.

URK-V594_COA

URK-V594_SDS

URK-V594_TDS

 

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