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GSK3368715 Trihydrochloride CAS No.: 2227587-26-8

Chemical Structure : GSK3368715 trihydrochloride
CAS No.: 2227587-26-8

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Description

Chemical Structure : GSK3368715 trihydrochloride

CAS No.: 2227587-26-8

GSK3368715 trihydrochloride

Catalog No.: URK-V2476 Only Used For Lab.

GSK3368715 trihydrochloride is a novel and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP), which plays a key role in promoting tumorigenesis and resistance to chemotherapy.

Biological Activity

GSK3368715 trihydrochloride is a novel and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP), which plays a key role in promoting tumorigenesis and resistance to chemotherapy.
Inhibition of XIAP by GSK3368715 trihydrochloride can induce apoptosis in cancer cells and sensitize them to chemotherapy.
GSK3368715 trihydrochloride is a small molecule inhibitor of the XIAP protein, which is an endogenous inhibitor of caspase-mediated apoptosis.

Physicochemical Properties

M.Wt	439.46
Formula	C₂₀H₄₀Cl₂N₄O₂
CAS No.	2227587-26-8
Appearance	Solid
Storage	Solide Powder -20 °C 3years; 4°C 2years	In Solvent -80°C 6 Months -20°C 1 Months
Solubility
Chemical Name

References

1. D'Arcy P et al. Abstract 3085: GSK3368715, a potent XIAP antagonist, exhibits single agent activity in multiple pre-clinical cancer models and enhances the efficacy of chemotherapy. Cancer Res. 2016;76(14 Suppl):3085.

2. Mezzasoma L et al. Antitumor activity of the XIAP antagonist GSK3368715 in preclinical models of hematologic and solid cancers. Cancer Invest. 2019;37(6):299-307.

3. Naik PK et al. Potent and selective small molecule inhibitors of XIAP-mediated protein-protein interactions. Angew Chem Int Ed Engl. 2018;57(26):7823-7827.