VU0453595 CAS No.: 1432436-13-9

Thank you for considering this product introduction of VU0453595, CAS No.: 1432436-13-9. This product is a highly sought-after compound used in the field of pharmaceutical research and development.

Introduction:

VU0453595 is a highly potent allosteric inhibitor of metabotropic glutamate receptor subtype 5 (mGlu5), making it an invaluable tool for advancing research in neurology and mental health. This compound is a breakthrough in the field of drug discovery, with its ability to selectively bind to mGlu5.

VU0453595 has a profound impact on the modulation of the glutamate system, which makes it an excellent candidate for investigating the pathophysiology of neurological disorders. In addition, this unique compound has the potential to revolutionize the treatment of illnesses such as Parkinson's disease, schizophrenia, and Huntington's disease.

Features and Benefits:

VU0453595 has many features and benefits that make it an attractive option for researchers and pharmaceutical companies alike. Firstly, this compound has a high potency, with a sub-nanomolar Ki against mGlu5. This means that it is highly effective in small quantities, making it a cost-effective option for those conducting research.

Secondly, VU0453595 has a high level of selectivity, which means that it has minimal off-target effects. This is crucial when it comes to developing a drug that is safe and effective, as it ensures that the compound has a highly specific effect on its target.

Thirdly, VU0453595 has excellent potential for the treatment of neurological disorders. Because of its unique ability to selectively modulate the glutamate system, this compound could have a significant impact on the development of new treatments for a wide range of neurological disorders.

Applications:

VU0453595 has many potential applications in both research and drug development. Researchers who are investigating the pathophysiology of neurological disorders, such as Parkinson's disease and Huntington's disease, could use this compound to gain a better understanding of the underlying mechanisms involved in these conditions.

Additionally, VU0453595 has great potential in the development of new therapies. Pharmaceutical companies could use this compound as a starting point for the design of new drugs that target mGlu5. This could lead to the development of new treatments for neurological disorders that are safer and more effective than current options.

Conclusion:

In conclusion, VU0453595 is a valuable compound for the field of neurological research and drug development. Its high potency, selectivity, and potential for the treatment of neurological disorders make it an attractive option for researchers and pharmaceutical companies alike. By utilizing this compound, researchers and drug developers can revolutionize the field of neurology and provide new and effective treatments for neurological disorders.

Chemical Structure : VU0453595

CAS No.: 1432436-13-9

 

VU0453595(VU 0453595;VU-0453595;VU453595)

Catalog No.: URK-V611 Only Used For Lab.

VU0453595 (VU453595) is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 3.2 uM (rM1)

Biological Activity

VU0453595 (VU453595) is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 3.2 uM (rM1); reverses deficits in social interaction and cognitive function observed in rodent model of schizophrenia.

Physicochemical Properties

References

1. Ghoshal A, et al. Neuropsychopharmacology. 2016 Jan;41(2):598-610.

2. Panarese JD, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3822-5.

3. Lv X, et al. Neuropharmacology. 2017 May 15;118:209-222.

4. Moran SP, et al. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771.

URK-V611_COA

URK-V611_SDS

URK-V611_TDS

 

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