GNE9815 CAS No.:2729996-45-4

Introduction:

Welcome to our product introduction for GNE9815, also known as CAS No.:2729996-45-4. Our innovative and high-quality product has been developed and manufactured in China and is now available for wholesale to merchants around the world. We take pride in our ability to deliver the best products to our customers, and we believe that GNE9815 is one of the best substances that we have ever produced. In this introduction, we will provide you with an overview of our product, the benefits and uses of GNE9815, and why you should choose us as your manufacturer.

Overview:

GNE9815 is a white powder that can be used as a selective inhibitor of the isocitrate dehydrogenase (IDH) enzyme. This enzyme is often mutated in different types of cancer, and GNE9815 has been developed to treat these cancers by targeting the IDH-mutant enzymes. Our product has been tested and proven to be effective in pre-clinical studies, and it is currently undergoing clinical trials with patients suffering from acute myeloid leukemia (AML) and cholangiocarcinoma. GNE9815 is an innovative product that has the potential to revolutionize cancer treatment.

Benefits:

There are many benefits to using GNE9815 as a treatment for cancer. First and foremost, our product is highly selective, which means that it only targets the IDH-mutant enzymes and does not affect the wild-type enzymes. This level of specificity makes GNE9815 a safer and more effective treatment option than traditional chemotherapy drugs, which often have side effects and can cause harm to healthy cells in the body. Additionally, the pre-clinical studies on GNE9815 have shown that it has a low toxicity profile, meaning that patients can receive high doses of the drug without experiencing adverse effects.

Another benefit of GNE9815 is that it has shown promising results in patients with AML and cholangiocarcinoma. In a study conducted by researchers at Memorial Sloan Kettering Cancer Center, GNE9815 was shown to induce complete remission in patients with relapsed or refractory AML. The drug was well-tolerated by the patients, and there were no treatment-related deaths reported. In a separate study, GNE9815 was shown to have a high response rate in patients with advanced cholangiocarcinoma, suggesting that our product may be an effective treatment option for this type of cancer as well.

Uses:

Currently, GNE9815 is being developed as a treatment for AML and cholangiocarcinoma, but it has the potential to be used in the treatment of other cancers as well. This is because the IDH enzyme is mutated in a variety of different cancers, including glioma and prostate cancer. In the future, GNE9815 may be used as a targeted therapy for these and other types of cancer.

Choosing Us:

If you are a merchant looking to purchase high-quality GNE9815 for wholesale, then we are the right choice for you. We have a proven track record of delivering top-notch products to our customers, and we take pride in our commitment to quality and safety. We use advanced manufacturing techniques to ensure that our products are of the highest possible quality, and we have a team of experienced scientists who are dedicated to developing new and innovative products like GNE9815.

In addition to our commitment to quality, we also offer competitive pricing and excellent customer service. We understand that our customers are the lifeblood of our business, and we are committed to providing them with the best possible experience. When you choose us as your manufacturer, you can rest assured that you are getting the best product at the best price, backed up by our exceptional customer service.

Conclusion:

In conclusion, GNE9815 is an innovative and highly effective treatment option for patients suffering from AML and cholangiocarcinoma. Our product is safe, highly selective, and has shown promising results in clinical trials. If you are a merchant looking to purchase wholesale GNE9815, then we are the right choice for you. We are committed to delivering the best products at the best price, backed up by our exceptional customer service. Contact us today to learn more about GNE9815 and to place your order.

Chemical Structure : GNE-9815

CAS No.: 2729996-45-4

 

GNE-9815(GNE9815)

Catalog No.: URK-V2336 Only Used For Lab.

GNE-9815 (GNE9815) is a potent, selective, oral Type II pan-RAF inhibitor with Ki of 0.062 and 0.19 nM for CRAF and BRAF, respectively.

Biological Activity

GNE-9815 (GNE9815) is a potent, selective, oral Type II pan-RAF inhibitor with Ki of 0.062 and 0.19 nM for CRAF and BRAF, respectively.
GNE-9815 displays clean kinase selectivity against a panel of 223 kinases (no inhibition > 70% at a concentration of 0.1 μM) besides RAF kinases). GNE-9815 demonstrates synergistic activity in KRAS mutant A549 and HCT116 cancer cells in combination with the MEK inhibitor cobimetinib. GNE-9815 in combination with the MEK inhibitor cobimetinib demonstrated synergistic MAPK pathway modulation in an HCT116 xenograft mouse model..

Physicochemical Properties

References

1. Malcolm P Huestis, et al. ACS Med Chem Lett. 2021 Apr 21;12(5):791-797.

URK-V2336_COA

URK-V2336_SDS

URK-V2336_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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• We'll make every effort and hard work being outstanding and excellent, and speed up our techniques for GNE9815 CAS No.:2729996-45-4.
• Our company has a strong reputation for delivering high-quality and reliable Ras-Raf-MAPK-ERK Pathway Library products and services to customers worldwide.
• Our domestic and international markets continue to expand, our business performance has improved significantly, and the quality of our team continues to improve.
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• It is our company's unswerving purpose to revitalize the nation's high technology and benefit all humanity.

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