TQB3804 CAS No.: 2267329-76-8

Introduction

TQB3804, also known as 2-[(2-chloroethyl)sulfonyl]ethyl 4-[4-(4-cyanophenoxy)phenyl]-6,7-dimethoxyquinazoline-2-carboxylate, is a novel and potent inhibitor of epidermal growth factor receptor (EGFR) kinase. As a leading manufacturer located in China, we are dedicated to offering high-quality TQB3804 to wholesalers and merchants in various countries. In this product introduction, we will delve into the features, benefits, and applications of TQB3804, with the aim of providing a comprehensive overview that can help merchants understand its value and place in the market.

Features

TQB3804 has several unique features that set it apart from other EGFR inhibitors on the market:

1. High potency: studies have shown that TQB3804 exhibits a high level of potency against EGFR kinase, which is a critical driver in the growth and proliferation of cancer cells.

2. Selectivity: TQB3804 has been shown to mitigate the activation of various EGFR family members while sparing other kinases, which is desirable in a drug that targets these pathways.

3. Oral bioavailability: TQB3804 has demonstrated favorable pharmacokinetic properties, making it an attractive candidate for oral administration.

Benefits

TQB3804 provides several benefits to both wholesalers and consumers. These advantages are derived from its unique features:

1. Efficacy: TQB3804 has demonstrated profound inhibitory effects on tumor growth, as well as the ability to sensitize tumors to radiation and chemotherapy. These findings support the potential of TQB3804 as a standalone or combinatory therapy for the treatment of cancer.

2. Safety: in preclinical studies, TQB3804 was found to be well-tolerated and did not affect the bodyweight of test subjects. This characteristic bodes well for its potential as a safe and effective therapy.

3. Convenience: oral bioavailability simplifies dosing regimens, making it an easy and convenient therapy for healthcare providers to prescribe, and patients to administer.

Applications

TQB3804 has a broad range of potential applications, particularly in the treatment of cancer. A detailed overview of its potential applications is as follows:

1. Non-small cell lung cancer (NSCLC): TQB3804 has shown promising results in the treatment of NSCLC, particularly in cases where the cancer has developed resistance to other EGFR inhibitors. It has the potential to be an alternative, effective therapy for these patients.

2. Triple-negative breast cancer (TNBC): TQB3804 has also shown promise in the treatment of TNBC, an especially aggressive and hard-to-treat form of breast cancer that is characterized by the absence of estrogen, progesterone, and HER2 receptors. TQB3804 has the potential to be a vital new treatment for this patient population.

3. Colorectal cancer: TQB3804 has also been studied in preclinical models of colorectal cancer, showing potent anti-tumor effects without producing any noticeable toxicities.

Conclusion

In conclusion, TQB3804 is a promising and novel inhibitor of EGFR kinase that possesses unique features, benefits, and applications. As a leading manufacturer in China, we are committed to offering high-quality TQB3804 to wholesalers and merchants worldwide. Its efficacy, safety, and oral bioavailability make it an attractive candidate for the treatment of cancer, particularly in cases where other EGFR inhibitors have failed. We look forward to working with our partners to bring this innovative and life-changing therapy to patients around the world.

Chemical Structure: Cilofexor

CAS No.: 2267329-76-8

 

EGFR-IN-7 (TQB-3804, EGFR-IN-7)

Catalog No.: URK-V589 Only Used For Lab.

TQB3804 (EGFR-IN-7) is a selective, potent, 3rd generation EGFR C797S inhibitor with IC50 of 1.07 nM and 0.13 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively.

Biological Activity

EGFR-IN-7 (TQB-3804) is a selective and potent EGFR kinase inhibitor with IC50 values of 0.46 nM for EGFRd746-750, T 793 nM, 0.76 nM, C797S, EGFRL858R / T790M / C 797 S, EGFRd746-750 / T790M, 0,0.16 nM, 0.17 nM and 1.07 nM, EGFRL858R / T790M and EGFRWT, respectively.
TQB3804 (EGFR-IN-7) also has antitumor activity.

Physicochemical Properties

References

URK-V589_COA

URK-V589_DataSheet

URK-V589_SDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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