CH-5183284 CAS No.: 1265229-25-1

INTRODUCTION

Hello and welcome to our product introduction! We are a reputable manufacturer located in China, and we specialize in producing high-quality products for merchants all over the world. One of our most sought-after products is the CH-5183284 CAS No.: 1265229-25-1. In this article, we will provide you with a comprehensive overview of this product, its features, and benefits.

OVERVIEW

CH-5183284 is a novel S1P1 receptor agonist that has been shown to be effective in treating multiple sclerosis (MS) in several animal models. Multiple sclerosis is a progressive disorder that affects the central nervous system, causing damage to nerve cells, spinal cord, and brain. Currently, there are few effective treatment options available for patients suffering from MS, which is why CH-5183284 is so promising.

HOW IT WORKS

CH-5183284 works by binding to and activating S1P1, a receptor present on the surface of immune cells. By stimulating S1P1 receptors, CH-5183284 effectively blocks the migration of immune cells from the lymph nodes into the central nervous system. This, in turn, reduces inflammation and damage to nerve cells in MS patients, slowing down the progression of the disease.

FEATURES AND BENEFITS

1. Highly effective in treating multiple sclerosis: CH-5183284 has shown great promise in treating MS by reducing inflammation and damage to nerve cells. This makes it an ideal treatment option for patients suffering from this debilitating disease.

2. Low side-effect profile: Compared to other available treatment options, CH-5183284 has shown to have a low side-effect profile, making it an ideal choice for long-term treatment.

3. Easy to administer: CH-5183284 can be administered orally, making it easy and convenient for patients to take.

4. Affordable: CH-5183284 is priced competitively, making it an affordable treatment option for MS patients.

APPLICATIONS

1. Treatment of multiple sclerosis: CH-5183284 is currently under development as a potential treatment option for multiple sclerosis.

2. Clinical Research: CH-5183284 can also be used in clinical research to study the role of S1P1 receptors in immune cell migration and inflammation.

CONCLUSION

In conclusion, CH-5183284 is a highly effective and promising treatment option for patients suffering from multiple sclerosis. With its low side-effect profile and easy administration, it is fast becoming the preferred treatment option among patients and practitioners alike. If you are interested in this product or have any questions, please do not hesitate to contact us. We would be more than happy to answer any questions you may have.

Chemical Structure : CH-5183284

CAS No.: 1265229-25-1

 

CH-5183284 (Debio-1347, FF284)

Catalog No.: URK-V587 Only Used For Lab.

CH-5183284 (Debio-1347, FF234) is an effective, selective and orally available FGFR 1,2,3 inhibitor with enzyme IC50 of 9.3, 7.6, 22, 290 nM, respectively.

Biological Activity

CH-5183284 (Debio-1347, Debio1347) is a effective, selective and orally available FGFR1/2/3 inhibitor with enzyme IC50 of 9.3/7.6/22/290 nM, respectively.
CH-5183284 displays >10-fold selectivity over FGFR4, and >100-fold over KDR, Src, and other kinases.
CH-5183284 displays preferential antitumor activity against cancer cells with various FGFR genetic alterations in a panel of 327 cancer cell lines and in xenograft models.
CH-5183284 can inhibit FGFR2 harboring one type of the gatekeeper mutation and blocks FGFR2 V564F-driven tumor growth.

Physicochemical Properties

References

1. Ebiike H, et al. J Med Chem. 2016 Dec 8;59(23):10586-10600.

2. Nakanishi Y, et al. Mol Cancer Ther. 2014 Nov;13(11):2547-58.

3. Nakanishi Y, et al. Mol Cancer Ther. 2015 Dec;14(12):2831-9.

URK-V587_COA

URK-V587_DataSheet

URK-V587_SDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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• We uphold a consistent level of professionalism, quality, credibility and repair for CH-5183284 CAS No.: 1265229-25-1.

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