ONO7475 CAS No.:1646839-59-9

Introduction

As a leading manufacturer based in China, we are committed to providing high-quality, reliable products to our global customers. Our latest addition to our product line, ONO7475 CAS No.:1646839-59-9, is a potent and selective inhibitor that has shown significant therapeutic potential in the treatment of cancer and other related diseases. In this product introduction, we will outline the key features and benefits of ONO7475, and explain why it is a must-have product for merchants looking to expand their portfolio in the pharmaceutical industry.

Overview of ONO7475

At its core, ONO7475 is a chemical compound that has demonstrated impressive anti-cancer properties. Specifically, it is an inhibitor of poly(ADP-ribose) polymerase (PARP) – an enzyme that plays a key role in the repair of DNA damage. By inhibiting PARP, ONO7475 disrupts the DNA damage response pathway in cancer cells, thereby compromising their ability to repair damaged DNA and proliferate.

Research has shown that ONO7475 has a high degree of selectivity for PARP1 and PARP2, the two most important PARP enzymes. Furthermore, it has been shown to be highly effective in several preclinical models of cancer, including breast, ovarian, and lung cancer, making it a promising drug candidate for cancer therapy.

Benefits of ONO7475

1. Potent anti-cancer activity – ONO7475 has shown to be highly effective in inhibiting PARP and preventing the growth and replication of cancer cells. This makes it a promising therapeutic candidate for various types of cancer, including those that have developed resistance to other treatments.

2. Selective targeting of cancer cells – ONO7475 has a high degree of selectivity for PARP1 and PARP2, which are overexpressed in many types of cancer cells. This means that it can effectively target cancer cells while minimizing damage to healthy cells.

3. Improved patient outcomes – Preliminary clinical results have shown that ONO7475 has the potential to improve patient outcomes by increasing overall survival rates and reducing the risk of disease progression.

4. Minimal side effects – Unlike many other cancer therapies, ONO7475 has been shown to have minimal side effects, making it a more tolerable treatment option for patients.

Applications of ONO7475

ONO7475 has the potential to be used in a wide range of cancer therapies, including monotherapy and combination therapy with other anti-cancer agents. Ongoing clinical trials are evaluating its efficacy and safety in different types of cancer, including breast, ovarian, and lung cancer. In addition, ONO7475 has also shown promise in the treatment of other diseases that are associated with DNA damage, such as inflammatory bowel disease and stroke.

Why choose us?

As a leading manufacturer of pharmaceuticals in China, we have years of experience in producing high-quality, reliable products. Our state-of-the-art facilities and highly trained staff ensure that we uphold the strictest standards of quality and safety in all our products. In addition, we offer competitive pricing and fast delivery times, making us the ideal partner for merchants looking for a reliable source of ONO7475.

Conclusion

In summary, ONO7475 is a highly promising inhibitor of PARP that has demonstrated significant anti-cancer activity in preclinical models. Its selective targeting of cancer cells, minimal side effects, and potential to improve patient outcomes make it a must-have product for merchants looking to expand their portfolio in the pharmaceutical industry. At our company, we are committed to providing high-quality products at competitive prices, and we invite merchants to partner with us to bring ONO7475 to the global market.

Chemical Structure : ONO-7475

CAS No.: 1646839-59-9

 

ONO-7475 (ONO7475)

Catalog No.: URK-V618 Only Used For Lab.

ONO-7475 (ONO7475) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations.

Biological Activity

ONO-7475 (ONO7475) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations.
ONO-7475 sensitizes AXL-expressing EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib.
ONO-7475 suppresses the emergence and maintenance of EGFR-TKI-tolerant cells, suppresses the phosphorylation of AKT, p70S6K, ERK, as well as EGFR. Combination therapy of ONO-7475 and osimertinib delays regrowth of cell line-derived xenograft tumors.
Osimertinib-acquired resistant cells are insensitive to combined therapy with osimertinib and ONO-7475.

Physicochemical Properties

References

1. Okura N, et al. Clin Cancer Res. 2020 May 1;26(9):2244-2256.

2. Ruvolo PP, et al. Haematologica. 2017 Dec;102(12):2048-2057.

URK-V618_COA

URK-V618_SDS

URK-V618_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

Why choose us?

• We use only the best quality raw materials to manufacture our Tyrosine Kinase Library products.
• We provide our customers with professional products and services of high quality and maximum value, and win their understanding, respect and support with our sincerity and strength.
• Our Tyrosine Kinase Library products are widely recognized for their exceptional quality and performance.
• We are committed to accelerating the company's industrial layout of diversified development and multi-polar support.
• Our prices are highly competitive, and we offer significant cost savings to our customers on bulk purchases of Tyrosine Kinase Library products.
• We have always paid attention to the quality of our ONO7475 CAS No.:1646839-59-9 and the construction of quality management system.
• Our team is always available to answer any questions you may have about our Tyrosine Kinase Library products.
• Our tenet is 'professional' and 'proficient', and we will provide you with safe, reliable and complete pre-sales and after-sales services. Welcome to call or write to us for consultation.
• We take great care to ensure that all our Tyrosine Kinase Library products meet the highest standards of quality.
• It is not difficult to improve customer loyalty, maintain good customer relationship and provide good customer service.

Hot Tags: ono7475 cas no.:1646839-59-9, China ono7475 cas no.:1646839-59-9, inhibitors for rna interference, epigenetic library for epigenetic analysis of non coding rna, agonists for neurotrophic factor activity, epigenetic library for epigenetic analysis of epigenetic variation, epigenetic library for epigenetic analysis of epigenetic adaptation, epigenetic library for epigenetic resilience