DDR1 Inhibitor 7rh CAS No.:1429617-90-2

DDR1 Inhibitor 7rh CAS No.:1429617-90-2 - A Revolutionary Product to Boost Your Business

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Overview of DDR1 Inhibitor 7rh CAS No.:1429617-90-2:

DDR1 Inhibitor 7rh CAS No.:1429617-90-2 is a small molecule inhibitor of DDR1 (discoidin domain receptor 1) kinase, which blocks the binding of DDR1 to collagen. DDR1 is a transmembrane receptor tyrosine kinase that is involved in cell proliferation, differentiation, migration, and survival. Recent studies have demonstrated that DDR1 is over-expressed in many solid tumors and plays a crucial role in tumor growth and metastasis. DDR1 inhibitor could be used to treat solid tumors that express DDR1.

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Chemical Structure : DDR1 inhibitor 7rh

CAS No.: 1429617-90-2

 

 

 

 

DDR1 inhibitor 7rh 

Catalog No.: URK-V2348 Only Used For Lab.

DDR1 inhibitor 7rh is a potent, selective, ATP-competitive, orally available Discoidin domain receptor 1 (DDR1) inhibitor with IC50 of 6.8 nM in cell-free kinase assays.

Biological Activity

DDR1 inhibitor 7rh is a potent, selective, ATP-competitive, orally available Discoidin domain receptor 1 (DDR1) inhibitor with IC50 of 6.8 nM in cell-free kinase assays; DDR1 inhibitor 7rh is significantly less potent in suppressing the kinase activities of DDR2 (IC50=101 nM), Bcr-Abl (IC50=355 nM), and c-Kit (IC50>10 uM); inhibits DDR1-mediated signaling induced by soluble collagen (50 μg/ml) in a concentration-dependent manner, inhibits activation of PYK2 and PEAK1, signaling proteins downstream of DDR1 in PANC-1 cells; induces significant decrease of total protein levels of DDR1 and Bcl-xL, causes a significant reduction in the level of MMP-2 in NSCLS cells; suppresses the growth of K562 human CML cells with IC50 of 38 nM, A549, NCI-H23 and NCI-H460 human NSCLC cells with IC50 of 2.7, 2.1 and 3.0 µM, respectively; abrogates collagen-induced DDR1 signaling in pancreatic tumor cells and consequently reduces colony formation and migration, exhibits striking efficacy in combination with chemotherapy in orthotopic xenografts and autochthonous pancreatic tumors.

Physicochemical Properties

References

1. Aguilera KY, et al. Mol Cancer Ther. 2017 Nov;16(11):2473-2485.

2. Gao M, et al. J Med Chem. 2013 Apr 25;56(8):3281-95.

URK-V2348_COA

URK-V2348_SDS

URK-V2348_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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