TPX0046 CAS No.:2359650-19-2

TPX0046 is an innovative and highly effective product that has quickly gained popularity among merchants around the world. This product is a highly specialized and top-quality offering that is designed for use in a wide range of industries and applications.

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TPX0046 is a highly versatile product that has many applications, and can be used in a variety of different industries. For example, it is often used in the pharmaceutical industry, where its high purity and quality make it an ideal candidate for use in the production of medicines.

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Chemical Structure : TPX-0046

CAS No.: 2359650-19-2

 

 

 

 

TPX-0046 (TPX0046)

Catalog No.: URK-V2335 Only Used For Lab.

TPX-0046 (TPX0046) is a potent, selective next-generation RET/SRC inhibitor, demonstrates low nanomolar potency against WT and 18 RET mutations/fusions, as well as SRC, and is VEGFR2/KDR-sparing.

Biological Activity

TPX-0046 (TPX0046) is a potent, selective next-generation RET/SRC inhibitor, demonstrates low nanomolar potency against WT and 18 RET mutations/fusions, as well as SRC, and is VEGFR2/KDR-sparing.
TPX-0046 inhibited RET phosphorylation (IC50 < 10 nM) in tumor cell lines (LC2/ad, CCDC6-RET; TT, RET C634W) and Ba/F3 engineered RET models (WT, G810R).
TPX-0046 inhibited KIF5B-RET Ba/F3, LC2/ad, and TT cells with IC50 values of 1 nM in cell proliferation assays.
TPX-0046 potently inhibited Ba/F3 RET engineered cells with SFMs (e.g. G810C/R/S) with mean proliferation IC50 of 1-17 nM.
TPX-0046 demonstrated marked in vivo anti-tumor efficacy in RET-driven cell-derived and patient-derived xenograft tumor models, a single dose of 5 mg/kg TPX-0046 inhibited >80% of RET phosphorylation.
TPX-0046 is a unique next-generation RET inhibitor that possesses potent in vitro and in vivo activity against a diverse range of RET alterations, including SFM-mediated resistance.

Physicochemical Properties

References

1. A.Drilon, et al. Annals of Oncology Volume 30, Supplement 5, October 2019, Pages v190-v191

URK-V2335_COA

URK-V2335_SDS

URK-V2335_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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• All of our TPX0046 CAS No.:2359650-19-2 are designed by international standards, with our own professional design team and excellent quality.

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