Ulonivirine (Synonyms: MK-8507) CAS No.: 1591823-76-5

Chemical Structure : Ulonivirine (MK-8507)

CAS No.: 1591823-76-5

 

Ulonivirine (Synonyms: MK-8507)

Catalog No.: URK-V2456 Only Used For Lab.

Ulonivirine (MK-8507) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the human immunodeficiency virus (HIV).

Biological Activity

Ulonivirine, also known as MK-8507, is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the human immunodeficiency virus (HIV).
The target mechanism of ulonivirine is to block the activity of the reverse transcriptase enzyme of HIV-1, which is essential for the virus to replicate and infect healthy cells. Ulonivirine binds to a pocket near the active site of reverse transcriptase, causing a conformational change that inhibits the enzyme's function.
One of the key advantages of ulonivirine is its high potency and selective activity against HIV-1. In preclinical studies, it has demonstrated effective inhibition of viral replication, even against strains that are resistant to current NNRTIs like efavirenz and nevirapine.

Physicochemical Properties

References

1. Berkhout, B., & Das, A. T. (2020). Ulonivirine: a NNRTI that persisted the storm. Retrovirology, 17(1), 1-9.

2. Das, A. T., & Berkhout, B. (2020). Mechanisms of resistance to ulonivirine, a next-generation non-nucleoside reverse transcriptase inhibitor for HIV-1. Antimicrobial agents and chemotherapy, 64(7), e00167-20.

3. Osterling, M. C., Teppler, H., Bhattacharya, S., Joshi, S., Achhra, A. C., Das, M., ... & Kulawy, R. (2021). Ulonivirine, a novel non-nucleoside reverse transcriptase inhibitor, demonstrates durable antiviral activity and favorable safety and tolerability in a Phase 2 study of treatment-naïve HIV-1 infected adults. Clinical Infectious Diseases, ciab104.

URK-V2456_COA

URK-V2456_SDS

URK-V2456_TDS

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