Limonianin (Synonyms: Atalantoflavone) CAS No.: 119309-02-3

Chemical Structure : Limonianin (Synonyms: Atalantoflavone)

CAS No.: 119309-02-3

 

Limonianin (Synonyms: Atalantoflavone)

Catalog No.: URK-V2508 Only Used For Lab.

Limonianin inhibit the activation of NF-κB, a transcription factor that promotes the expression of various inflammatory and tumor-promoting genes. It achieves this by preventing the phosphorylation of IκBα, which is required for the degradation of the inhibitor of NF-κB. This results in the accumulation of IκBα, inhibiting the translocation of NF-κB to the nucleus and the subsequent gene expression.

Biological Activity

Limonianin has been shown to inhibit the activity of the enzyme 5-lipoxygenase (5-LOX), which is responsible for the production of leukotrienes, potent inflammatory mediators. It achieves this by directly binding to the active site of 5-LOX, preventing the conversion of arachidonic acid to leukotrienes. In addition, limonianin has been reported to inhibit the expression of cyclooxygenase-2 (COX-2), another enzyme involved in the production of inflammatory mediators, by blocking the activation of NF-κB.

Physicochemical Properties

References

1.Liang YR, Huang YL, Tsai SH, Lin-Shiau SY, Chen CF, Lin JK. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis. 1999;20(10):1945-1952.

2.Guo J, Wang CF. Limonianin of citrus fruit as a potential therapeutic agent: a comprehensive review. Expert Opin Ther Targets. 2020;24(1):1-17.

3.Ghosh J, Das J, Manna P, Sil PC. Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Appl Pharmacol. 2009;240(1):397-414.

4.Wu Y, Zheng J, Liu J, Deng X, Bai M, Liu T, Wu Z, Li Y. Limonianin suppresses inflammatory responses by blocking the NF-kappa B signaling pathway in lipopolysaccharide-induced RAW 264.7 macrophages. J Agric Food Chem. 2016;64(46):8850-8857.

URK-V2508_COA

URk-V2508_SDS

URK-V2508_TDS

Hot Tags: Limonianin (Synonyms: Atalantoflavone) CAS No.: 119309-02-3, China Limonianin (Synonyms: Atalantoflavone) CAS No.: 119309-02-3, inhibitors for differentiation, inhibitors for gene expression, agonists for joint repair, inhibitors for neurodegenerative diseases, agonists for inflammation research, agonists for skin grafting