FSEN1 CAS No.: 862808-01-3

Chemical Structure : FSEN1

CAS No.: 862808-01-3

 

FSEN1

Catalog No.: URK-V2478 Only Used For Lab.

FSEN1 selectively targets the NF-κB pathway, a signaling cascade that plays a crucial role in the regulation of immune responses. By inhibiting this pathway, FSEN1 effectively blocks the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, while simultaneously promoting the expression of anti-inflammatory mediators, such as IL-10.

Biological Activity

FSEN1 selectively targets the NF-κB pathway, a signaling cascade that plays a crucial role in the regulation of immune responses. By inhibiting this pathway, FSEN1 effectively blocks the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, while simultaneously promoting the expression of anti-inflammatory mediators, such as IL-10.

Physicochemical Properties

References

1．Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1(6):a001651.

2．Jadhav BB, Mahajan UB, Patil KR, et al. A small molecule inhibitor of NF-κB blocks the TNF-α-induced increase in IL-6 and IL-8 production in bronchial epithelial cells. Sci Rep. 2017;7:17339.

3．Buser DP, McArthur RL, Lewis RA, et al. Novel inhibitors targeting the IKK–NF-κB pathway: discovery and optimization of furanone-based compounds with anti-inflammatory activity in vivo. J Med Chem. 2020;63(19):11125-11147.

URK-V2478_COA

URK-V2478_SDS

URK-V2478_TDS

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