BMS986235 CAS No.:2253947-47-4

Introduction:

Thank you for your interest in our product, the BMS986235 (CAS No.: 2253947-47-4). We are a renowned manufacturer of high-quality chemicals based in China, and we specialize in the development and production of innovative and cost-effective products that meet the needs of our customers worldwide.

BMS986235 is a novel potent and selective inhibitor of SCD1, which is an important enzyme in lipid metabolism. It can regulate gene expression and metabolic pathways and plays a critical role in the development of various conditions, including obesity, cancer, diabetes, and inflammation. Our product is a key component for researchers and scientists who are working on the development of new therapeutics for these conditions.

Key Features and Benefits:

BMS986235 stands out for its unique features and benefits, which include:

1. Potent and selective inhibition of SCD1:

BMS986235 is a highly potent and selective inhibitor of SCD1, which means it can exclusively target this enzyme without affecting other metabolic pathways. This feature ensures that our product can be used for a wide range of research and therapeutic applications without causing any unwanted side effects.

2. Increased efficacy in treating multiple conditions:

SCD1 inhibition has shown great efficacy in the treatment of a variety of conditions, such as obesity, cancer, and diabetes. By targeting this enzyme, BMS986235 can boost the efficacy of existing therapies or serve as a foundation for the development of new ones.

3. High bioavailability and low toxicity:

Our product has a high bioavailability, which means it can easily reach the target site within the body and start acting. At the same time, it has a very low toxicity profile, making it safe for use in a variety of research and therapeutic applications.

4. Versatile product:

BMS986235 has immense potential for research and therapeutic applications in various fields, including pharmacology, oncology, endocrinology, and metabolic disorders. It can be used in experiments to study the mechanisms underlying lipid metabolism, develop new drug candidates, or improve the efficacy of existing therapeutics.

Applications:

BMS986235 has a wide range of applications for researchers and scientists who are working on the development of new drugs or therapeutics for various conditions related to lipid metabolism. The following are a few examples of how our product can be used:

1. Development of new SCD1 Inhibitors:

BMS986235 can be used as a reference compound in the development of new SCD1 inhibitors that have higher efficacy, bioavailability, and selectivity. Researchers can utilize this compound to develop novel scaffolds by modifying its structure.

2. Investigation of Lipid Metabolism:

BMS986235 can be used in experiments designed to study the mechanisms underlying lipid metabolism. Researchers can use this compound to understand how the inhibition of SCD1 affects various metabolic pathways and gene expression.

3. Cancer Research:

SCD1 inhibition has shown great promise in the treatment of various types of cancer. BMS986235 can be used in experiments to study the cancer-promoting role of SCD1 in various types of cancer.

Conclusion:

In conclusion, BMS986235 is a novel and highly potent inhibitor of SCD1, which has immense potential in various fields of research and therapeutic applications. Our product stands out for its unique features, such as high potency, selectivity, and low toxicity, making it an ideal choice for researchers and scientists looking for high-quality chemicals for their experiments. We are confident that our product can help you achieve your research goals and contribute to the advancement of science and medicine.

Chemical Structure : BMS-986235

CAS No.: 2253947-47-4

 

 

 

 

BMS-986235 (LAR-1219)

Catalog No.: URK-V2352 Only Used For Lab.

BMS-986235 (LAR-1219) is a potent, selective, and orally bioavailable agonist of formyl peptide receptor 2 (FPR2) with EC50 of 0.4 nM (hFPR2), >7,000-fold selectivity over FPR1.

Biological Activity

BMS-986235 (LAR-1219) is a potent, selective, and orally bioavailable agonist of formyl peptide receptor 2 (FPR2) with EC50 of 0.4 nM (hFPR2), >7,000-fold selectivity over FPR1.
BMS-986235 produced concentration-dependent modulation of BRET signals for Gαi1, Gαi2, Gαi3, GαoA, and GαoB biosensors following FPR2 activation (EC50=5-13 nM), 164- to 614-fold selectivity over FPR1 activation.
BMS-986235 improved mouse survival, reduced left ventricular area, reduced scar area, and preserved wall thickness, inhibited neutrophil chemotaxis and stimulated macrophage phagocytosis, key end points to promote resolution of inflammation.
BMS-986235 preserved viable myocardium, attenuated left ventricular remodeling, and increased ejection fraction in rats following MI.

Physicochemical Properties

References

1. Yoshikazu Asahina, et al. J Med Chem. 2020 Sep 10;63(17):9003-9019.

2. Ricardo A García, et al. JACC Basic Transl Sci. 2021 Aug 23;6(8):676-689.

URK-V2352_COA

URK-V2352_SDS

URK-V2352_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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• The BMS986235 CAS No.:2253947-47-4 we produce is fully compliant with market standards and has achieved outstanding results with excellent production technology and high quality.

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