Cyclohexanemethanol, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, Trans- CAS No.: 2434841-21-9

Chemical Structure : Cyclohexanemethanol, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, trans-

CAS No.: 2434841-21-9

 

Cyclohexanemethanol, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, trans-

Catalog No.: URK-V2482 Only Used For Lab.

Cyclohexanemethanol, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, trans- one major target is the mitogen-activated protein kinase (MAPK) pathway. MAPK pathway plays a vital role in cell growth, proliferation and differentiation, and has been implicated in the progression of various cancers.

Biological Activity

Cyclohexanemethanol, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, trans- one major target is the mitogen-activated protein kinase (MAPK) pathway. MAPK pathway plays a vital role in cell growth, proliferation and differentiation, and has been implicated in the progression of various cancers.
Another major target of cyclohexanemethanol, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, trans- is the PI3K/Akt/mTOR pathway. The PI3K/Akt/mTOR pathway is aberrantly activated in various cancers and plays a key role in the regulation of cell growth and survival. Cyclohexanemethanol, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, trans- has been shown to effectively inhibit the activation of PI3K/Akt/mTOR pathway, thereby inducing apoptosis and inhibiting tumor growth.
Several studies have also reported the potential of cyclohexanemethanol, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, trans- as an inhibitor of other cancer-related pathways such as JAK/STAT and Wnt/β-catenin. Moreover, it has also been shown to exhibit anti-inflammatory and anti-oxidant properties, making it a potential therapeutic option for various inflammatory and oxidative stress-related diseases.

Physicochemical Properties

References

1. Liang X, Zhu J, Li W, et al. Cyclohexanemethanol, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, trans- inhibits the proliferation and invasion of triple-negative breast cancer cells by suppressing the PI3K/Akt/mTOR signaling pathway. Oncol Lett. 2020;19(2):1291-1298.

2. Patel J, Ng C, Tanwar J, et al. The cyclohexanemethanol derivative, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, trans-, inhibits JAK/STAT signaling in breast cancer cells. Pathol Oncol Res. 2020;26(4):2357-2366.

3. Zhao L, Zhou X, Wang L, et al. Cyclohexanemethanol, 4-[4-amino-3-(difluoromethyl)-1H-pyrazol-1-yl]-, trans-, inhibits the proliferation and migration of liver cancer cells by suppressing the Wnt/β-catenin signaling pathway. Biomed Res Int. 2020;2020:3019680.

URK-V2482_COA

URK-V2482_SDS

URK-V2482_TDS

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