IL-17 Modulator 4 CAS No.: 2446803-65-0

Chemical Structure : IL-17 modulator 4

CAS No.: 2446803-65-0

 

IL-17 modulator 4

Catalog No.: URK-V2488 Only Used For Lab.

IL-17 modulator 4 is a small molecule inhibitor that targets the interleukin-17 (IL-17) pathway.

Biological Activity

IL-17 modulator 4 is a small molecule inhibitor that targets the interleukin-17 (IL-17) pathway.
IL-17 modulator 4 inhibits the IL-17 pathway by selectively blocking the interaction between Act1 and IL-17R, thereby preventing the recruitment of downstream signaling proteins and the subsequent activation of proinflammatory pathways. IL-17 modulator 4 has been shown to have a high degree of selectivity for the IL-17 signaling pathway, with no significant effects on other cytokine signaling pathways.
IL-17 modulator 4 targets the IL-17 pathway by selectively inhibiting the activity of IL-17 signaling proteins. The IL-17 pathway is initiated by the activation of IL-17 receptors (IL-17R) on the surface of target cells, such as epithelial cells and fibroblasts. IL-17R activation leads to the recruitment of a number of signaling proteins, such as Act1 and TRAF6, which ultimately activate downstream signaling pathways, such as NF-κB and MAPK, leading to the expression of proinflammatory cytokines.
IL-17 modulator 4 inhibits the IL-17 pathway by selectively blocking the interaction between Act1 and IL-17R, thereby preventing the recruitment of downstream signaling proteins and the subsequent activation of proinflammatory pathways. IL-17 modulator 4 has been shown to have a high degree of selectivity for the IL-17 signaling pathway, with no significant effects on other cytokine signaling pathways.

Physicochemical Properties

References

1.Dan, Y. et al. (2018). Small-molecule Targeting of IL-17 Signaling for the Treatment of Inflammatory Diseases. Cell Chemical Biology, 25: 1350-1360.e5.

2.Xie, Y. et al. (2017). Small-molecule Inhibitor Targeting the IL-17 Signaling Pathway Improves Multiple Parameters of Psoriasis-like Skin Disease in Mice. Journal of Pharmacology and Experimental Therapeutics, 361: 303-311.

URK-V2488_COA

URK-V2488_SDS

URK-V2488_TDS

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