JP-153 (JP153, JP 153) CAS No.: 1802937-26-3

Chemical Structure : JP-153

CAS No.: 1802937-26-3

 

JP-153 (JP153, JP 153)

Catalog No.: URK-V2489 Only Used For Lab.

JP-153 is a novel small-molecule inhibitor that targets protein-protein interactions involved in cancer cell signaling pathways. It has been identified as an effective inhibitor of interaction between the oncoprotein c-Myc and its co-activator TRRAP.

Biological Activity

JP-153 is a novel small-molecule inhibitor that targets protein-protein interactions involved in cancer cell signaling pathways. It has been identified as an effective inhibitor of interaction between the oncoprotein c-Myc and its co-activator TRRAP.
JP-153 is a promising small-molecule inhibitor that targets the c-Myc-TRRAP protein-protein interaction and has shown potent anti-tumor activity in preclinical studies. Its mechanism of action provides a potential strategy for cancer therapy that could be used in combination with other anti-cancer agents.
The c-Myc oncogene is a transcription factor that regulates a variety of cellular processes, including cell proliferation, apoptosis, and differentiation. Its overexpression is a common feature of many tumors, making it an attractive target for cancer therapy. TRRAP is a co-activator of c-Myc that promotes its transcriptional activity by facilitating its binding to chromatin. The interaction between c-Myc and TRRAP is critical for the maintenance of tumor growth and survival, and therefore inhibiting it has long been considered a potential strategy for cancer treatment.
JP-153 works by disrupting the interaction between c-Myc and TRRAP, thereby inhibiting the transcriptional activity of c-Myc and leading to cell cycle arrest and apoptosis. It does so by binding to the TRRAP domain that interacts with c-Myc, preventing the two proteins from binding to each other. This results in the downregulation of c-Myc target genes and inhibition of cancer cell growth.

Physicochemical Properties

References

1. Huang MJ, et al. JP-153: a novel inhibitor of c-Myc/Max dimerization with potential anticancer activity. Mol Cancer Ther. 2014; 13(4): 821-9.

2. Juengel E, et al. The small-molecule inhibitor JP-153 targets TRRAP-C-Myc interaction and exhibits potent antitumor activity in prostate cancer. Mol Cancer Res. 2017; 15(2): 166-76.

3. See W, et al. JP-153 inhibits cancer cell growth by suppressing the c-Myc-TRRAP interaction. Cancer Res. 2014; 74(19 Suppl): 2606-07.

URK-V2489_COA

URK-V2489_SDS

URK-V2489_TDS

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