4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine CAS No.: 1211520-73-8

Chemical Structure : 4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine

CAS No.: 1211520-73-8

 

4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine

Catalog No.: URK-V2471 Only Used For Lab.

4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (CTPP) , functions as a kinase inhibitor, is a potent inhibitor of the protein kinases CK1δ/ε.

Biological Activity

4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (CTPP) , functions as a kinase inhibitor, is a potent inhibitor of the protein kinases CK1δ/ε, which are involved in regulating various cellular processes and have been implicated in the development of cancer, neurodegenerative diseases, and metabolic disorders.
Research has shown that CTPP is highly effective in inhibiting CK1δ/ε activity, and has displayed promising results in preclinical studies as a potential treatment for Huntington's disease, breast cancer, and Alzheimer's disease.

Physicochemical Properties

References

1. Mora A, Komander D, van Aalten DMF, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol. 2004;15(2):161-170.

2. Tao J, Wu H, Lin Q, et al. Structure and Activity of a Highly Specific Protein Kinase CK1δ Modulator. Cell Chem Biol. 2019;26(8):1115-1126.e10.

3. Xiao X, Yu J, Wu D, et al. Identification and characterization of a specific inhibitor of CK1ε. J Mol Cell Biol. 2016;8(1):38-46.

4. Silva JM, Rodrigues J, Sola P, et al. The pyrrolo[2,3-d]pyrimidine derivative CTPP inhibits breast cancer cell proliferation by promoting p53-mediated apoptosis. Eur J Med Chem. 2014;87:675-682.

URK-V2471_COA

URK-V2471_SDS

URK-V2471_TDS

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