PCNA-I 1 CAS No.:444930-42-1

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Introducing PCNA-I 1: The Revolutionary Chemical Compound That Will Revolutionize Your Business

As a manufacturer, it is our constant desire to create products that can help boost your business to the next level. We know how competitive the market is, and we understand that you need reliable and effective products to give you an edge over your competitors. This is why we are excited to introduce our latest product, the PCNA-I 1, a game-changing chemical compound that has the potential to transform your business.

The PCNA-I 1 is a ground-breaking chemical compound that promises to deliver superior quality and performance compared to its competitors. With its unique molecular structure, it has the ability to enhance the functionality of various industrial processes, making it an essential component in a wide range of applications. It has been extensively tested and proven to be highly effective, with excellent properties that make it the perfect solution for your business needs.

So what makes PCNA-I 1 different from other chemical compounds? Let's take a closer look at its features and benefits.

Features:

1. High Purity - We use only the highest quality raw materials to manufacture our PCNA-I 1. This ensures that our product is free from impurities that can affect its performance.

2. Unique Molecular Structure - Our chemical compound has a unique molecular structure that enhances its functionality, making it an essential component in a wide range of applications.

3. Superior Quality - We follow strict quality control measures to ensure that every batch of our product meets the highest standards of quality and performance.

Benefits:

1. Increased Efficiency - PCNA-I 1 has been proven to increase the efficiency of various industrial processes, resulting in greater productivity and lower costs.

2. Enhanced Performance - Our chemical compound has excellent properties that enhance the performance of your products and processes, thereby improving their overall quality.

3. Cost-Effective - Despite its superior performance, PCNA-I 1 is competitively priced, making it a cost-effective solution for businesses of all sizes.

Applications:

PCNA-I 1 is versatile and can be used in various industrial applications. Here are some of the industries and applications where our product can be used:

1. Pharmaceutical Industry - PCNA-I 1 is an essential component in the synthesis of various drugs.

2. Agrochemical Industry - Our product is a vital ingredient in the manufacture of herbicides, fungicides, and insecticides.

3. Semiconductor Industry - PCNA-I 1 is used in the production of high-quality semiconductors.

4. Chemical Industry - Our product is used in the synthesis of specialty chemicals, specialty polymers, and advanced materials.

Conclusion:

In today's highly competitive market, businesses need products that can help them stay ahead of the game. With PCNA-I 1, you have an opportunity to revolutionize your business processes with a chemical compound that delivers superior quality and performance. Our product is versatile, cost-effective, and boasts unique features that will transform your industrial applications. So why wait? Contact us today to get your hands on the game-changing PCNA-I 1 and take your business to the next level!

Chemical Structure : PCNA-I1

CAS No.: 444930-42-1

 

PCNA-I1(PCNA inhibitor 1)

Catalog No.: URK-V2025  Only Used For Lab.

PCNA-I1 is a small molecule inhibitor of proliferating cell nuclear antigen (PCNA), selectively binds to PCNA trimers with Kd of 0.14-0.41 uM, inhibits the growth of tumor cells of various tissue types with IC50 of 0.2 uM.

Biological Activity

PCNA-I1 is a small molecule inhibitor of proliferating cell nuclear antigen (PCNA), selectively binds to PCNA trimers with Kd of 0.14-0.41 uM, inhibits the growth of tumor cells of various tissue types with IC50 of 0.2 uM. PCNA-I1 dose- and time-dependently reduced the chromatin-associated PCNA in cells, affected the growth of nontransformed cells at significantly higher concentrations (IC50=1.6 uM).
PCNA-I1 also dose-dependently reduced uptake of BrdU in PCNA-I1 treated cells, induced cancer cell arrest at both the S and G(2)/M phases.
PCNA-I1 induced DNA damage and apoptosis in both LNCaP (wild-type p53) and PC-3 cells (p53-null) and enhanced DNA damage and apoptosis triggered by cisplatin, also induced autophagy in PC-3 cells.
PCNA-I1 (i,v.) significantly retarded growth of LNCaP tumors of in nude mice without causing detectable effects on mouse body weight and hematology profiles.

Physicochemical Properties

References

1. Tan Z, et al. Mol Pharmacol. 2012 Jun;81(6):811-9.

2. Dillehay KL, et al. Mol Cancer Ther. 2014 Dec;13(12):2817-26.

URK-V2025_COA

URK-V2025_SDS

URK-V2025_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

Why choose us?

• Our philosophy is to focus on quality over quantity, ensuring that each product is made to the highest standard.
• We have a large scale, complete product range and series, competitive and influential.
• We are both a supplier and manufacturer of these products, ensuring competitive pricing.
• We firmly believe in 'quality is benefit, quality is the lifeblood of the enterprise'.
• We are committed to providing our customers with the best products at a competitive price.
• Our PCNA-I 1 CAS No.:444930-42-1 have complete functions, stable and reliable performance, and are one of the best choices for many customers.
• Our manufacturing process is streamlined to ensure consistent product quality and fast turnaround times.
• We establish a corporate image with quality and service, create corporate benefits with efficient management, forge ahead, and take off together with new and old customers at home and abroad!
• Our high-quality products are trusted by leading researchers and institutions around the world.
• The company seeks development in competition and seeks opportunities in challenges.

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