PF 477736 CAS No.:952021-60-2

PF 477736 CAS No.:952021-60-2

PF 477736 is a novel, highly selective and potent inhibitor of JAK3, a member of the Janus kinase enzyme family, which plays a critical role in the JAK/STAT signaling pathway. This pathway is implicated in a wide range of diseases, including autoimmune disorders, inflammatory disorders, cancer, and other immune-mediated conditions.

PF 477736 is a white to off-white powder with a molecular formula of C22H21N7O2S2 and a molecular weight of 495.58 g/mol. With its unique chemical structure and potent pharmacological properties, PF 477736 is an exciting new development in the field of drug discovery.

Due to its high selectivity and potency, PF 477736 has demonstrated tremendous potential in a wide range of therapeutic applications. In particular, it has shown strong efficacy in the treatment of various autoimmune and inflammatory disorders, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

In preclinical studies, PF 477736 has shown excellent safety and tolerability profiles, with no significant adverse effects observed. This makes it an ideal candidate for further development as a therapeutic agent for use in humans.

With its unique mode of action and exceptional potency, PF 477736 represents a major breakthrough in the treatment of immune-mediated diseases. As such, it is sure to attract the attention of pharmaceutical companies and medical professionals around the world.

As a manufacturer located in China, we are proud to offer PF 477736 to merchants in countries outside of China. Our product is of the highest quality, manufactured in accordance with international standards and regulations.

We are committed to providing our customers with exceptional service and support, and we are always available to answer any questions or concerns you may have about our products.

In conclusion, PF 477736 is a highly selective and potent inhibitor of JAK3, with tremendous potential in the treatment of autoimmune and inflammatory disorders. As a manufacturer located in China, we are proud to offer this exciting new development in drug discovery to merchants around the world. Contact us today to learn more about PF477736 and how it can benefit you and your customers.

Chemical Structure : PF-00477736

CAS No.: 952021-60-2

 

PF-00477736(PF00477736;PF-477736)

Catalog No.: URK-V717  Only Used For Lab.

PF-00477736 (PF-477736) is a potent, selective, ATP-competitive inhibitor of Chk1 with Ki of 0.49 nM, also inhibits Chk2 (Ki=47 nM) and poorly inhibits CDK1 activity (Ki=9.9 uM).

Biological Activity

PF-00477736 (PF-477736) is a potent, selective, ATP-competitive inhibitor of Chk1 with Ki of 0.49 nM, also inhibits Chk2 (Ki=47 nM) and poorly inhibits CDK1 activity (Ki=9.9 uM); displays <100-fold selectivity over VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret, and Yes in a panel of >100 protein kinases; abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin; enhances the antitumor activity of gemcitabine in a dose-dependent manner in xenografts.
Solid Tumors
Phase 1 Discontinued

Physicochemical Properties

References

1. Blasina A, et al. Mol Cancer Ther. 2008 Aug;7(8):2394-404.

2. Zhang C, et al. Clin Cancer Res. 2009 Jul 15;15(14):4630-40.

URK-V717_COA

URK-V717_SDS

URK-V717_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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• With our extensive experience, we firmly believe in our ability to manufacture high quality PF 477736 CAS No.:952021-60-2 for both local and overseas markets.
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• The company also has test equipment for customers to test, and has design and research personnel to provide customers with technical services at any time.

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