FEN1-IN-7 CAS No.: 824983-90-6

Chemical Structure : FEN1-IN-7

CAS No.: 824983-90-6

 

FEN1-IN-7

Catalog No.: URK-V2502 Only Used For Lab.

FEN1-IN-7 is a novel, potent and selective inhibitor of Flap endonuclease 1 (FEN1), a critical enzyme involved in DNA replication and repair. FEN1-IN-7 has been shown to exhibit anticancer activity by inducing DNA damage and cell cycle arrest in various cancer cell lines.

Biological Activity

FEN1-IN-7 is a novel, potent and selective inhibitor of Flap endonuclease 1 (FEN1), a critical enzyme involved in DNA replication and repair. FEN1-IN-7 has been shown to exhibit anticancer activity by inducing DNA damage and cell cycle arrest in various cancer cell lines.
FEN1, a structure-specific nuclease, plays an essential role in DNA replication and the maintenance of genome stability. FEN1 is involved in removing RNA primers and cleaving replication intermediates during Okazaki fragment maturation and repair processes. Evidence suggests that dysregulated FEN1 expression or activity may contribute to the development and progression of cancer, making it an attractive therapeutic target.
FEN1-IN-7 inhibits FEN1 activity by binding to the enzyme's active site, preventing it from functioning. The specific interactions between FEN1 and FEN1-IN-7 have been elucidated through molecular docking studies and further confirmed through biochemical and biological assays.
Status in drug development:
FEN1-IN-7 has shown significant promise as a potential anticancer agent. It exhibits robust activity against several cancer cell lines, including those resistant to conventional chemotherapy. In preclinical studies, FEN1-IN-7 has been shown to induce DNA damage, activate cell death pathways, and promote cell cycle arrest. Importantly, FEN1-IN-7 also demonstrates good pharmacokinetic properties that make it a promising candidate for further clinical development.

Physicochemical Properties

References

1. Zhao, Q. et.al. Discovery and optimization of quinazolinone-4-amides as potent inhibitors targeting the Flap endonuclease 1 (FEN1) for cancer therapy. J Med Chem. 2018 Feb 8;61(3):1311-1326.

2. Zhang, Y. et al. Development of novel FEN1 inhibitors for targeted cancer therapy. Bioorg Med Chem Lett. 2020 Nov 1; 30(21): 127504.

URK-V2502_COA

URk-V2502_SDS

URK-V2502_TDS

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