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BMS-1166 Hydrochloride CAS No.: 2113650-05-6

Chemical Structure : BMS-1166 hydrochloride
CAS No.: 2113650-05-6

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Description

Chemical Structure : BMS-1166 hydrochloride

CAS No.: 2113650-05-6

BMS-1166 hydrochloride

Catalog No.: URK-V2479 Only Used For Lab.

BMS-1166 hydrochloride (CAS No.: 2113650-05-6) is a novel small molecule inhibitor, specifically targets PIM kinases, a family of serine/threonine kinases.

Biological Activity

BMS-1166 hydrochloride is a novel small molecule inhibitor, specifically targets PIM kinases, a family of serine/threonine kinases.
BMS-1166 have ability to bind to the ATP-binding pocket of PIM kinases, preventing their activation and downstream signaling.
BMS-1166 displays a high selectivity for PIM kinases, with no significant impact on other kinases or cellular pathways.

Physicochemical Properties

M.Wt	677.57
Formula	C₃₆H₃₄Cl₂N₂O₇
CAS No.	2113650-05-6
Appearance	Solid
Storage	Solide Powder -20 °C 3years; 4°C 2years	In Solvent -80°C 6 Months -20°C 1 Months
Solubility
Chemical Name

References

1. Brown JR, et al. Safety, pharmacokinetics, and pharmacodynamics of single agent BMS-1166 in patients with advanced hematological malignancies: Initial results from a phase 1/2a study. 2019 American Society of Hematology.

2. Brault L, et al. PIM kinases are potential therapeutic targets in multiple myeloma. Blood. 2012;119(3):865-75.

3. Kadavakollu S, et al. PIM kinase inhibitors enhance the effectiveness of mammalian androgen receptor antagonists against prostate cancer cells. Oncotarget. 2017;8(19):31437-50.