DPI-201-106 CAS No.:97730-95-5

DPI-201-106 CAS No.: 97730-95-5 - The Ultimate Solution for Your Industrial Needs

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Chemical Structure : DPI 201-106

CAS No.: 97730-95-5

 

DPI 201-106(SDZ 201106)

Catalog No.: URK-V2218 Only Used For Lab.

DPI 201-106 (SDZ 201106) is a positive inotropic agent that prolongs the open state of cardiac voltage-gated Na+ channels.

Biological Activity

DPI 201-106 (SDZ 201106) is a positive inotropic agent that prolongs the open state of cardiac voltage-gated Na+ channels.
DPI 201-106 produced concentration-dependent positive inotropic effects in guinea-pig and rat left atria, kitten, rabbit and guinea-pig papillary muscles and Langendorff perfused hearts of rabbits between 0.1-3 uM.
DPI 201-106 increased the Ca2+-sensitivity of skinned fibres from porcine trabecula septomarginalis with EC50 of 0.2 nM.
DPI (1-100 uM) suppressed the amplitude of delayed-rectifier K+ current (I(K(DR))) in a concentration-dependent manne with IC50 of 6.4 uM.
DPI-201106 also selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines.

Physicochemical Properties

References

1. Scholtysik G, et al. Naunyn Schmiedebergs Arch Pharmacol. 1985 May;329(3):316-25.

2. Buggisch D, et al. Eur J Pharmacol. 1985 Dec 3;118(3):303-11.

3. Scholtysik G, et al. Eur J Pharmacol. 1986 Jun 5;125(1):111-8.

4. Hsiao SH, et al. Cancer Lett. 2018 Oct 10;434:81-90.

URK-V2218_COA

URK-V2218_SDS

URK-V2218_TDS

 

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