PF-04745637 CAS No.:1917294-46-2

Introduction:

Welcome to our product introduction of PF-04745637, a highly potent and selective inhibitor of the TRPC channels developed by our team of expert researchers and scientists. As a leading manufacturer in China, we are proud to offer this innovative product to merchants in countries outside of China. In this article, we will introduce the characteristics and advantages of PF-04745637, and hopefully provide you with a comprehensive understanding of this revolutionary chemical component.

Background:

TRPC ion channels play important roles in diverse physiological processes such as smooth muscle contraction, cardiac activity, and sensory perception. TRPC channels have been linked to a wide range of clinical disorders such as hypertension, arrhythmia, allergy, chronic pain, and cancer. Targeting TRPC channels has drawn considerable attention as a promising therapeutic strategy.

Our research team in China has successfully developed PF-04745637, which is a highly potent and selective small molecule inhibitor of TRPC channels. It has been shown to be effective in vitro and in vivo models of diseases related to TRPC channels. Here are some of the key aspects of our product which we believe make it an indispensable component of modern-day industry.

Main benefits and advantages:

1. Potent and Selective Inhibition

PF-04745637 has demonstrated high potency and selectivity in TRPC channels inhibition. It provides a specific and efficient way to research the functions of TRPC channels in biological systems, which makes it an indispensable tool in life sciences research. By selectively identifying and inhibiting TRPC channels, our product can reduce the risk of adverse effects from multi-target drugs. This characteristic is of great significance in the research of many clinical disorders that are related to TRPC channels, such as hypertension, arrhythmia, allergy, chronic pain, and cancer.

2. Innovative Mechanism of Action

Our team has discovered a unique mechanism of action for PF-04745637. We have found that PF-04745637 directly binds to and closes the ion channel pores, which effectively blocks the influx of Ca2+ ions through TRPC channels. This then prevents downstream signaling and biological responses regulated by TRPC channels. Therefore, our product provides a novel approach to research the functions of TRPC channels, which is of great importance in developing new therapies to counteract diseases related to TRPC channels.

3. Research and Drug Development Applications

The unique characteristics of PF-04745637 make it highly applicable in the development of new drugs targeting TRPC channels. Because of the significant role that these channels play in many diseases, researchers are actively looking for ways to inhibit or potentiate these channels’ functions. PF-04745637 can be an essential tool to find and validate new drugs for clinical trials. Moreover, researchers could use our product to discover new candidate drugs, design new chemical entities, and develop structure-activity relationships for TRPC channels inhibitors, which can ultimately lead to more effective treatments for clinical disorders linked with TRPC channels.

4. Competitive Pricing

As a leading manufacturer in China, we understand that the cost of research is an essential consideration for merchants. Our product offers industry-leading quality at highly competitive prices. With our efficient supply chain management, we can guarantee timely delivery and excellent customer service, which are critical components in today's fast-paced business environment.

Conclusion:

In conclusion, our product, PF-04745637, provides a potent and selective TRPC channels inhibition approach. With its innovative mechanism of action, our product helps researchers uncover new insights into TRPC channel functions, and drives the development of new drugs to combat diseases related to these channels. Given its multiple advantages and benefits, we are confident that our product will play a pivotal role in accelerating innovation and discovery in the fields of biochemistry, pharmacology, and life sciences. It is our great pleasure to offer our product to merchants worldwide, and we are confident that it will yield remarkable results in their research and drug development efforts.

Chemical Structure : PF-04745637

CAS No.: 1917294-46-2

 

PF-04745637(PF 04745637, PF04745637)

Catalog No.: URK-V655 Only Used For Lab.

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1

Biological Activity

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1

Physicochemical Properties

References

Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809.

URK-V655_COA

URK-V655_SDS

URK-V655_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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• We want to develop into a PF-04745637 CAS No.:1917294-46-2 production, R&D and sales manufacturer with first-class core technology and international influence.

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