AZD9496 CAS No.:1639042-08-2

Introduction

Do you want to offer your customers a product that can help them combat cancer? Or do you want to take advantage of the global trend towards precision medicine? We would like to introduce you to our product AZD9496 CAS No.:1639042-08-2. AZD9496 is a small molecule drug that selectively inhibits estrogen receptor alpha (ERα) transcriptional function. The product is suitable for research purposes and has shown promising results in preclinical cancer models.

What is AZD9496 CAS No.:1639042-08-2?

AZD9496 is a selective ERα modulator that can bind to and inhibit the activity of estrogen receptors in cancer cells. As such, it can selectively kill and inhibit the growth of cancer cells that rely on the activity of the estrogen receptor (ER) signaling pathway. The potency and selectivity of AZD9496 have been demonstrated in vitro and in vivo.

Product specifications

AZD9496 CAS No.:1639042-08-2 is a white solid powder with a purity of >98% and a molecular weight of 401.89. It is soluble in DMSO, methanol, and ethanol but insoluble in water. The product is available in various packaging sizes from 1mg to 50g, and the product can also be customized according to the customer's requirements.

Applications

AZD9496 CAS No.:1639042-08-2 is useful in breast and ovarian cancer research, as well as in other ER-dependent cancers. It can be used in cancer research models to study the role of the estrogen receptor signaling pathway, and to identify new targets for cancer therapy. Additionally, it has shown promise in combination with other drugs, including those that target PI3K or cyclin-dependent kinases (CDKs).

Mechanism of action

AZD9496 CAS No.:1639042-08-2 selectively modulates the activity of estrogen receptor alpha (ERα). The drug can bind to the ligand-binding domain of ERα, which inhibits the transcriptional activity of ERα. As a result, AZD9496 prevents the binding of estrogen to ERα and the subsequent activation of the signaling pathway, leading to the selective killing of cancer cells that rely on the estrogen signaling pathway.

Benefits

AZD9496 CAS No.:1639042-08-2 has several benefits that make it a good choice for cancer research studies. The product is potent and selective and can selectively inhibit the growth of cancer cells that rely on the activity of the estrogen receptor signaling pathway. Additionally, AZD9496 has high oral availability and good bioavailability, which makes it suitable for use in studies in vivo. Furthermore, the product is easy to use and cost-effective, making it an attractive option for researchers who want to advance their understanding of cancer biology.

Summary

AZD9496 CAS No.:1639042-08-2 is a promising product for researchers studying estrogen receptor-dependent cancers. The drug is potent and selective, and it can selectively inhibit the growth of cancer cells that rely on the activity of the estrogen receptor signaling pathway. Additionally, AZD9496 has high oral availability and good bioavailability, making it a good choice for in vivo studies. If you are interested in learning about how AZD9496 CAS No.:1639042-08-2 can further cancer research or provide effective therapies, reach out to us at your earliest convenience. We can help you explore our product line and identify whether AZD9496 CAS No.:1639042-08-2 is effective for your particular cancer research needs.

Chemical Structure : AZD9496

CAS No.: 1639042-08-2

 

AZD9496(AZD-9496)

Catalog No.: URK-V691 Only Used For Lab.

A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.

Biological Activity

A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68; shows pM equipotent binding to both ERα and ERβ isoforms, highly selective binding compared with progesterone (∼650-fold), glucocorticoid (∼11,223-fold), and androgen (∼36,375-fold) receptor LBDs; downregulator of ERα in vitro and in vivo in ER-positive models of breast cancer and orally available.
Breast Cancer
Phase 1 Clinical

Physicochemical Properties

References

1. De Savi C, et al. J Med Chem. 2015 Oct 22;58(20):8128-40.

2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.

3. Toy W, et al. Cancer Discov. 2017 Mar;7(3):277-287.

URK-V691_COA

URK-V691_SDS

URK-V691_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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