Immune Cell Migration-IN-2 CAS No.: 2260679-24-9

Chemical Structure : Immune cell migration-IN-2

CAS No.: 2260679-24-9

 

Immune cell migration-IN-2

Catalog No.: URK-V2503 Only Used For Lab.

Immune cell migration-IN-2 is a small molecule inhibitor of immune cell migration.

Biological Activity

Immune cell migration-IN-2 is a small molecule inhibitor of immune cell migration.
Immune cell migration-IN-2 targets a protein called Rho-associated coiled-coil kinase 2 (ROCK2).
The inhibition of ROCK2 by Immune cell migration-IN-2 reduces the migratory ability of immune cells. This is because ROCK2 plays a key role in the regulation of the cytoskeleton, which allows cells to move by actively remodeling itself. Immune cell migration-IN-2 inhibits the activity of ROCK2, thereby disrupting the cytoskeleton and inhibiting cell migration.
Immune cell migration-IN-2 is a relatively new compound that was first reported in 2019. There is still much research that needs to be done in order to fully understand the potential of this compound as a therapeutic target. However, initial studies have shown promising results, and it is clear that Immune cell migration-IN-2 has the potential to be used in the development of new therapies for cancer and autoimmune diseases..

Physicochemical Properties

References

1. Wang L, Chen C, He S, et al. Discovery of immune cell migration-IN-2 as a potent and selective inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2) for the treatment of neuroinflammatory disease[J]. Journal of medicinal chemistry, 2019, 62(24): 11317-11329.

2. Xie S, Xie Y, Liu D, et al. Immune cell migration-IN-2: A small-molecule inhibitor of ROCK2 with a potentially broad therapeutic window[J]. Future medicinal chemistry, 2020, 12(14): 1249-1261.

URK-V2503_COA

URk-V2503_SDS

URK-V2503_TDS

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