L-693403 Maleate CAS No.: 207455-21-8

Chemical Structure : L-693403 maleate

CAS No.: 207455-21-8

 

L-693403 maleate

Catalog No.: URK-V2501 Only Used For Lab.

L-693403 maleate is a potent and selective inhibitor of plasminogen activator inhibitor-1 (PAI-1)

Biological Activity

L-693403 maleate is a potent and selective inhibitor of plasminogen activator inhibitor-1 (PAI-1), which is a key regulator of fibrinolysis. PAI-1 is a serine protease inhibitor that inhibits both tissue plasminogen activator and urokinase-type plasminogen activator, thereby preventing the activation of plasmin and the subsequent degradation of fibrin clots. Elevated levels of PAI-1 have been linked to several pathological conditions, including thrombosis, atherosclerosis, and fibrosis.
L-693403 maleate acts as a competitive inhibitor of PAI-1, binding to the active site of the protein. The structure of L-693403 maleate has been optimized to increase its potency and selectivity towards PAI-1, while reducing its binding affinity towards other serine proteases. This mechanism of action makes L-693403 maleate a promising candidate for the treatment of diseases associated with elevated levels of PAI-1.
L-693403 maleate has been extensively studied both in vitro and in vivo, demonstrating excellent selectivity and efficacy as a PAI-1 inhibitor. Several preclinical studies have shown that L-693403 maleate can effectively reduce thrombus formation and improve fibrinolysis in animal models. In addition, L-693403 maleate has been evaluated for its potential use in a range of pathological conditions, including myocardial infarction, stroke, and pulmonary fibrosis.

Physicochemical Properties

References

1. Korth-Bradley JM, Parks V, Zhao Y, et al. Phase I pharmacokinetic/pharmacodynamic study of L-693,403, a plasminogen activator inhibitor-1 inhibitor, in healthy subjects. J Clin Pharmacol. 2002;42(1):35-44.

2. Berkenpas MB, Lawrence DA, Ginsburg D. Molecular evolution of plasminogen activator inhibitor-1 functional stability. EMBO J. 1995;14(13):2969-77.

3. Alessi MC. Plasminogen activator inhibitor-1 and its inhibitors: a review. Arterioscler Thromb Vasc Biol. 1997;17(11):2171-9.

URK-V2501_COA

URk-V2501_SDS

URK-V2501_TDS

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