PS-423 CAS No.: 1221964-37-9

Chemical Structure : PS-423

CAS No.: 1221964-37-9

 

PS-423

Catalog No.: URK-V2487 Only Used For Lab.

PS-423 is a novel and potent inhibitor of PTP-1B.

Biological Activity

PS-423 is a novel and potent inhibitor of PTP-1B
PS-423 is primarily known for its ability to inhibit the protein target PTP-1B. PTP-1B is a protein tyrosine phosphatase that plays a significant role in regulating insulin sensitivity and glucose homeostasis. It is also implicated in cancer progression and immune system regulation. Inhibition of PTP-1B by PS-423 has been shown to improve glucose tolerance, insulin sensitivity, and reduce body weight in obese animals.
PS-423 exerts its inhibitory effects by binding to the active site of PTP-1B, preventing it from dephosphorylating its substrates. This leads to an increase in tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1), resulting in improved insulin signaling and glucose uptake. Furthermore, PS-423 also targets other proteins such as SHP-2 and Src homology domain-containing phosphatase 2 (SHP2), leading to its broad spectrum therapeutic potential.

Physicochemical Properties

References

1. Heinrichs AH et al. "Discovery and optimization of potent, orally active, and selective phosphatase and tensin homolog (PTEN) inhibitors based on the 3-hydroxychromen-4-one scaffold." J Med Chem. 2015 Jul 9;58(13):5211-27.

2. Wang L et al. "Preclinical efficacy and mechanism of action of PS-423, a novel and selective inhibitor of protein tyrosine phosphatase-1B." Mol Pharmacol. 2013 Apr;83(4):835-46.

URK-V2487_COA

URK-V2487_SDS

URK-V2487_TDS

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