SV 156 CAS No.: 873445-60-4

Chemical Structure : SV 156

CAS No.: 873445-60-4

 

SV 156

Catalog No.: URK-V2500 Only Used For Lab.

SV 156 is a novel small molecule inhibitor. The target of this inhibitor is the mitogen-activated protein kinase (MAPK) pathway, a signaling pathway that plays a crucial role in cell growth, division, and survival.

Biological Activity

SV 156 is a novel small molecule inhibitor. The target of this inhibitor is the mitogen-activated protein kinase (MAPK) pathway, a signaling pathway that plays a crucial role in cell growth, division, and survival.
The mechanism of inhibition of SV 156 is based on its ability to bind and inhibit the activity of the dual-specificity phosphatase 16 (DUSP16), also known as mitogen-activated protein kinase phosphatase 7 (MKP-7), a negative regulator of the MAPK pathway. As a result, the inhibition of DUSP16 leads to the activation of the MAPK pathway and the downstream signaling cascades that contribute to various diseases.
Recent studies have shown that SV 156 has potential therapeutic applications in several conditions, including cancer, inflammatory disorders, and neurodegenerative diseases. In preclinical studies, the inhibition of DUSP16 by SV 156 leads to the activation of the MAPK pathway and results in the inhibition of cancer cell growth, while also reducing inflammation in animal models of inflammatory diseases.
The development of SV 156 is ongoing, and several clinical trials have been initiated to test its safety and efficacy in various clinical settings. Additionally, the identification of new targets and the development of derivatives of SV 156 are being investigated to improve its pharmacological profile and therapeutic potential.

Physicochemical Properties

References

1. Zhang Y, Blattman JN, Kennedy NJ, et al. Molecular pharmacology of phosphate inhibitors targeting the dual-specificity phosphatase MKP-7. Drug discovery today. 2018;23(10):1840-1847.

2. Sangwan V, Paliwal N, Rani M, et al. SV156, a novel inhibitor of MKP-7, exerts anti-inflammatory effects in macrophages and ameliorates experimental colitis in mice. International immunopharmacology. 2019;75:105811.

3. Yang SH, Sharrocks AD. Target identification of small molecules via in vitro identification of protein-ligand interactions. Expert opinion on drug discovery. 2017;12(1):99-107.

URK-V2500_COA

URk-V2500_SDS

URK-V2500_TDS

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