Flt-3 Inhibitor III CAS No.: 852045-46-6

Introduction:

Flt-3 Inhibitor III is a chemical compound that belongs to the class of tyrosine kinase inhibitors, which selectively targets a specific enzyme known as Fms-like tyrosine kinase 3 (Flt-3). The Flt-3 enzyme plays a crucial role in the development and proliferation of hematopoietic stem cells and is commonly found to be overexpressed in various types of leukemia, particularly acute myeloid leukemia (AML). Flt-3 Inhibitor III has been extensively researched as a potential treatment for Flt-3-driven leukemia and has shown promising results.

Features and Advantages:

1. Selective Inhibition: Flt-3 Inhibitor III specifically targets Flt-3 kinase activity, which distinguishes it from other tyrosine kinase inhibitors that may have broader effects on multiple enzymes. This selective inhibition enhances the drug's effectiveness while minimizing unwanted side effects.

2. Potent and Efficacious: Preclinical studies have demonstrated the potent anti-proliferative effects of Flt-3 Inhibitor III against Flt-3-driven leukemia cells. In addition, the drug has shown impressive potency in inhibiting the growth of human primary AML cells, making it an attractive drug candidate for clinical testing.

3. Diverse Applications: Apart from leukemia, further studies have suggested that Flt-3 Inhibitor III also has the potential to treat other Flt-3-driven cancers, such as breast and germ cell tumors. This versatility makes Flt-3 Inhibitor III a promising molecule for a wide range of cancer applications.

4. Synergistic Effects: When used in combination with other chemotherapeutic drugs, Flt-3 Inhibitor III has demonstrated synergistic effects, resulting in enhanced anti-leukemic activity. This combination approach can potentially lead to more effective treatment regimes.

5. ADMET Profile: The drug has excellent absorption, distribution, metabolism, and excretion (ADMET) characteristics, which are crucial in drug development. Flt-3 Inhibitor III has a low possibility of causing toxicities and can be easily administered through oral or intravenous routes.

Conclusion:

Flt-3 Inhibitor III is a novel and promising tyrosine kinase inhibitor that selectively targets Flt-3 kinase activity, resulting in potent and effective anti-leukemic activity. Its unique features, such as selectivity, potency, and versatility, make it an attractive drug candidate in the fight against leukemia and other Flt-3-driven cancers. Its excellent ADMET profile and potential for synergistic combinations with other chemotherapeutic agents are additional advantages that can make it a valuable addition to the current oncology drug pipeline. As a manufacturer located in China, we are proud to offer Flt-3 Inhibitor III to merchants worldwide, and we are committed to supporting innovative drug discoveries that can benefit the lives of patients worldwide.

Chemical Structure : Flt-3 Inhibitor III

CAS No.: 852045-46-6

 

Flt-3 Inhibitor III

Catalog No.: URK-V2377  Only Used For Lab.

Flt-3 Inhibitor III, a receptor tyrosine kinase, is a potent and selective small molecules FLT3 kinase inhibitor. Flt-3 Inhibitor III plays a significant role in leukaemogenesis.

Biological Activity

Flt-3 Inhibitor III, a receptor tyrosine kinase, is a potent and selective small molecules FLT3 kinase inhibitor.
Flt-3 Inhibitor III plays a significant role in leukaemogenesis.
Flt-3 Inhibitor III may be effective used in combination with other molecularly targeted agents, in postchemotherapy stem-cell-directed maintenance therapy and in MLL-rearranged infant acute lymphoblastic leukaemia.
Flt-3 Inhibitor III shows anticancer fuction.
FLT-3 kinase inhibitors are currently under investigation as a new treatment for acute myeloid leukemia. 

Physicochemical Properties

References

[1] Pascal Furet, et al. J Med Chem. 2006 Jul 27;49(15):4451-4.

[2] Br J Haematol. 2007 Sep;138(6):687-99.

URK-V2377_COA

URK-V2377_SDS

URK-V2377_TDS

 

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