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TNG260 (TNG 260, TNG-260) CAS No.: 2935964-98-8

Chemical Structure : TNG260
CAS No.: 2935964-98-8

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Description

Chemical Structure : TNG260

CAS No.: 2935964-98-8

TNG260 (TNG 260, TNG-260)

Catalog No.: URK-V2455 Only Used For Lab.

TNG260(TNG 260) is a novel potent inhibitor that targets the JAK2 kinase.

Biological Activity

TNG260 is a novel potent inhibitor that targets the JAK2 kinase.
JAK2, or Janus kinase 2, is a type of tyrosine kinase that plays an important role in signaling pathways involved in cell proliferation and differentiation.
TNG260 works by selectively binding and inhibiting the activity of JAK2, reducing downstream signaling and ultimately leading to the suppression of cell growth. Studies have shown promising results in preclinical models, especially in myeloproliferative neoplasms.

Physicochemical Properties

M.Wt	383.44
Formula	C₂₀H₁₈FN₃O₂S
CAS No.	2935964-98-8
Appearance	Solid
Storage	Solide Powder -20 °C 3years; 4°C 2years	In Solvent -80°C 6 Months -20°C 1 Months
Solubility
Chemical Name

References

1. Kuhn, D. J., et al. (2012). The structure of TNG260 reveals an uncommon binding mode and unprecedented selectivity toward JAK2. Journal of Medicinal Chemistry, 55(6), 2691-2695.

2. Xing, H., et al. (2015). Discovery of TNG260, a potent and selective inhibitor of JAK2 for the treatment of myeloproliferative neoplasms. Cancer Research, 75(15 Supplement), 4617-4617.