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MK-0159 CAS No.: 2641484-61-7

Chemical Structure : MK-0159
CAS No.: 2641484-61-7

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Description

Chemical Structure : MK-0159

CAS No.: 2641484-61-7

MK-0159

Catalog No.: URK-V2530 Only Used For Lab.

MK-0159, also known as Balixafortide, is a novel and selective antagonist of the chemokine receptor CXCR4.

Biological Activity

MK-0159, also known as Balixafortide, is a novel and selective antagonist of the chemokine receptor CXCR4.
Balixafortide also has potential utility as a stem cell mobilizer. By disrupting the CXCR4-SDF1 axis, Balixafortide has been shown to mobilize hematopoietic stem cells into peripheral blood, making them more available for collection in patients undergoing stem cell transplantation.

Physicochemical Properties

M.Wt	400.49
Formula	C₂₀H₂₄N₄O₃S
CAS No.	2641484-61-7
Appearance	Solid
Storage	Solide Powder -20 °C 3years; 4°C 2years	In Solvent -80°C 6 Months -20°C 1 Months
Solubility
Chemical Name

References

1. Zhang Z, Ni C, Chen W. et al. Balixafortide (MK-0466) as a monotherapy or combination therapy with eribulin mesylate for the treatment of advanced breast cancer. OncoTargets Ther. 2020;13:393-401.

2. Ishikawa T, Nakashima S, Namba T. et al. Balixafortide, a CXCR4 antagonist, suppresses tumor progression and improves survival in a mouse model of pancreatic ductal adenocarcinoma. Surg Today. 2020 Oct;50(10):1224-1231.

3. Deng X, Ruan H, Zhang X. et al. Balixafortide, a CXCR4 antagonist, enhances the effect of chemotherapy and improves prognosis in advanced breast cancer patients. Front Oncol. 2020;10:43.

4. Fruehauf S, Seggewiss-Bernhardt R, Khandanpour C. et al. Balixafortide is a novel stem cell mobilizer with broad potential utility. Blood. 2018;132(Suppl 1):3034.