GDC046 CAS No.:1258292-64-6

GDC046 CAS No.:1258292-64-6 is an innovative product that has been at the forefront of the pharmaceutical industry. It is a highly sought-after solution that is known for its high efficacy and safety. This product is manufactured in China and is a top choice for merchants looking to stock highly effective pharmaceutical products.

The product is a potent inhibitor of EGFR and HER2 that is designed to inhibit the growth of cancer cells. Its unique molecular structure allows it to have the ability to bind specifically to the receptors on the surface of cancer cells, targeting and killing them effectively.

GDC046 CAS No.:1258292-64-6 comes from the family of therapies known as small molecule inhibitor drugs. This type of therapy uses small molecules to interact with specific molecular targets to achieve desired results. These molecules are highly effective because they have a high degree of specificity and selectivity, which means they can target cancer cells without damaging healthy cells.

One of the critical features of GDC046 CAS No.:1258292-64-6 is that it has a long-lasting effect. Once the medication is ingested, it can remain in the system for an extended period of time, allowing for continuous treatment. The long-lasting effect is beneficial for patients who may miss scheduled doses or who may be unable to take medication due to their daily schedules.

Another notable feature of GDC046 CAS No.:1258292-64-6 is its ability to penetrate the blood-brain barrier. The blood-brain barrier is a protective membrane that surrounds the brain and prevents harmful substances from entering. However, this barrier also makes it challenging for drugs to reach the brain when treating brain-related diseases. The ability of GDC046 to penetrate the blood-brain barrier is essential for treating cancers that originate in the brain.

GDC046 CAS No.:1258292-64-6 is also known for its minimal side effects. This is because the small molecule inhibitor drug targets only the cancer cells, sparing healthy cells and tissues from damage. Many other traditional cancer treatments, such as chemotherapy and radiation, often cause severe side effects, which can be debilitating to patients. The minimal side effects associated with GDC046 CAS No.:1258292-64-6 make it a more comfortable and tolerable treatment option.

In conclusion, GDC046 CAS No.:1258292-64-6 is a highly effective and safe treatment option for cancer patients. Its unique molecular structure, long-lasting effects, ability to penetrate the blood-brain barrier, and minimal side effects make it a top choice for healthcare professionals looking to treat cancer. As a manufacturer located in China, we are proud to offer this product to merchants worldwide who are looking for a reliable and high-quality pharmaceutical product. We are committed to providing excellent service and product quality, and we look forward to a long-lasting partnership with our valued customers.

Chemical Structure : GDC-046

CAS No.: 1258292-64-6

 

GDC-046(GDC046)

Catalog No.: URK-V619 Only Used For Lab.

GDC-046 is a potent, selective, and orally bioavailable inhibitor of TYK2 with with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively.

Biological Activity

GDC-046 is a potent, selective, and orally bioavailable inhibitor of TYK2 with with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively; GDC-046 demonstrates reasonable potency in blocking the IL-12 pathway (IL-12 pSTAT4 EC50=380 nM) in cell based assays, also displays less activity in the EPO (JAK2) pathway (EPO pSTAT5 EC50=1700 nM), and IL-6 (JAK1) pathway (IL-6 pSTAT3 EC50=2000 nM). GDC-046 shows statistically significant knockdown of cytokine interferon-γ (IFNγ), in a mouse IL-12 PK/PD model.

Physicochemical Properties

References

1. Yu-Ki Tahara, et al. J Am Chem Soc. 2018 Feb 14;140(6):2105-2114.

2. Qin S, et al. J Immunol. 2020 Oct 15;205(8):2231-2242.

3. Zhang L, et al. Redox Biol. 2021 Apr;40:101848.

URK-V619_COA

URK-V619_SDS

URK-V619_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

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