PF-07258669 CAS No.: 2755890-53-8

Chemical Structure : PF-07258669

CAS No.: 2755890-53-8

 

PF-07258669

Catalog No.: URK-V2513 Only Used For Lab.

PF-07258669 is a selective and potent inhibitor of the protein kinase enzyme known as PI3Kδ.

Biological Activity

PF-07258669 is a selective and potent inhibitor of the protein kinase enzyme known as PI3Kδ.
PF-07258669 has strong inhibitory effects on PI3Kδ, with an IC50 value of less than 10 nM. It has also been found to be highly selective for this target, with minimal effects on other related PI3K enzymes.
PF-07258669 has shown promising activity in treating inflammatory and autoimmune diseases.
It has been found to be effective in reducing the activity of B cells and T cells, which are known to contribute to these conditions.
PF-07258669 may have potential as a treatment for diseases such as rheumatoid arthritis, lupus, and multiple sclerosis.

Physicochemical Properties

References

1. Yang Q, et al. Discovery of PF-07258669: A Potent PI3Kδ Inhibitor with Macrocyclic Architecture for the Treatment of Inflammatory and Autoimmune Diseases. J Med Chem. 2021 Apr 8. doi: 10.1021/acs.jmedchem.0c01651.

2. Martin AL, et al. A novel, potent, and selective phosphoinositide 3-kinase δ (PI3Kδ) inhibitor blocks leukocyte recruitment in inflammation. J Biol Chem. 2021 Apr 30;296:100595. doi: 10.1016/j.jbc.2021.100595.

URK-V2513_COA

URk-V2513_SDS

URK-V2513_TDS

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