Description
Chemical Structure : GNE-1858
CAS No.: 2680616-96-8
GNE-1858
Catalog No.: URK-V2527 Only Used For Lab.
GNE-1858 is a novel small molecule inhibitor that has been developed to block the signaling pathway of the Rho guanine nucleotide exchange factor (RGNEF) protein. This protein plays a critical role in the activation of the Rho GTPases, which regulates cell morphology, motility, and adhesion. The inhibition of this process by GNE-1858 has been shown to reduce the invasive capability of cancer cells, making it a promising therapeutic candidate for cancer treatment.
Biological Activity
GNE-1858 is a novel small molecule inhibitor that has been developed to block the signaling pathway of the Rho guanine nucleotide exchange factor (RGNEF) protein. This protein plays a critical role in the activation of the Rho GTPases, which regulates cell morphology, motility, and adhesion. The inhibition of this process by GNE-1858 has been shown to reduce the invasive capability of cancer cells, making it a promising therapeutic candidate for cancer treatment.
GNE-1858 against various cancer cell lines, such as breast cancer, prostate cancer, and ovarian cancer.
Physicochemical Properties
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M.Wt |
428.48 |
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Formula |
C21H26F2N8 |
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CAS No. |
2680616-96-8 |
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Appearance |
Solid |
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Storage |
Solide Powder -20 °C 3years; 4°C 2years |
In Solvent -80°C 6 Months -20°C 1 Months |
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Solubility |
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Chemical Name |
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References
1. Premnath PN et al. (2017). Identification of a novel Rho guanine nucleotide exchange factor inhibitor for cancer treatment. Nat Commun 8(1): 1182.
2. Kim JH et al. (2019). Targeting the Rho GTPase pathway for cancer therapy. Arch Pharm Res 42(1): 1-14.
3. Wang Y et al. (2020). Development of small molecule inhibitors targeting the Rho GTPase pathway in cancer. Cancer Lett 495: 34-44.
URK-V2527_COA
URk-V2527_SDS
URK-V2527_TDS
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